Genetic differentiation of the malaria vector Anopheles gambiae across Nigeria suggests that selection limits gene flow

Heredity
D Y Onyabe, Jan E Conn

Abstract

Gene flow was investigated in Anopheles gambiae from eight localities that span the ecological zones of Nigeria (arid savanna zones in the north gradually turn into humid forest zones in the south). Genetic differentiation was measured over 10 microsatellite loci and, to determine any effects of selection, five loci were located within chromosome inversions and the other five were outside inversions. Over all loci, the largest estimates of differentiation were in comparisons between localities in the savanna vs. forest zones (range FST 0.024-0.087, Nm 2.6-10.1; RST 0.014-0.100, Nm 2.2-16.4). However, three loci located within inversions on chromosome II, whose frequencies varied clinically from north to south, were responsible for virtually all of the differentiation. When the three loci were removed, genetic distances across the remaining seven loci were markedly reduced even between localities in the forest and savanna zones (range FST 0.001-0.019, Nm 12.7-226.1) or no longer significant (P > 0.05) in the case of RST. Although tests of isolation by distance gave seemingly equivocal results, geographical distance does not appear to limit gene flow. These observations suggest that gene flow is extensive across the country but t...Continue Reading

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Citations

Aug 17, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·D Y OnyabeJ E Conn
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Nicholas C ManoukisNora J Besansky
Dec 28, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Rafael F GuerreroMark Kirkpatrick
Dec 1, 2008·Annual Review of Ecology, Evolution, and Systematics·Ary A Hoffmann, Loren H Rieseberg
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Jan 6, 2016·Parasites & Vectors·Iresha Nilmini HarischandraBambaranda Gammacharige Don Nissanka Kolitha De Silva
Aug 26, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·J R LoaizaJ E Conn
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