[Genetic diseases of the retinal pigment epithelium].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
M N Preising, B Lorenz

Abstract

The retinal pigment epithelium (RPE) is a cellular monolayer between the choriocapillaris and the photoreceptors which controls the uptake of nutrients by the retina and the disposal of shed photoreceptor outer segments from the retina. The RPE is responsible for a continuous supply of rhodopsin by the retinol cycle and blocking of light by its pigmentation to minimize light-induced oxidation of retinal lipids and proteins. Proteins encoded by genes in which mutations are responsible for hereditary disorders of the retina and the RPE are involved in all these functions. In this article these genes and disorders are reviewed in the context of a functional network.

References

Dec 31, 1997·The Journal of Biological Chemistry·T NakanoH Arita
Mar 4, 2000·Human Molecular Genetics·P M D'CruzD Vollrath
Jan 25, 2002·Archives of Ophthalmology·Joost FeliusPaul A Sieving
Jul 3, 2003·Nature Reviews. Molecular Cell Biology·Michael J BerridgeH Llewelyn Roderick
Jan 28, 2004·The Journal of Cell Biology·Yoshikazu ImanishiKrzysztof Palczewski
Apr 28, 2004·Investigative Ophthalmology & Visual Science·Christina L McHenryDebra A Thompson
Sep 29, 2004·Investigative Ophthalmology & Visual Science·Jill YardleyGraeme C M Black
Nov 27, 2004·The Journal of Physiology·Rodolphe Fischmeister, H Criss Hartzell
Jan 20, 2005·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·B Lorenz, M N Preising
Dec 2, 2005·The Journal of Biological Chemistry·Gennadiy MoiseyevJian-Xing Ma
Apr 14, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·B WabbelsB Lorenz
Jul 28, 2006·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Swaantje PetersUlrich Schraermeyer
Nov 24, 2006·Investigative Ophthalmology & Visual Science·Yusuke TakahashiJian-xing Ma
Feb 1, 2007·Annual Review of Biochemistry·Suzanne R Pfeffer
Feb 24, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sylvie JulienUlrich Schraermeyer
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Bryan L KrockBrian D Perkins
May 26, 2007·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M N PreisingB Lorenz
Jun 27, 2007·Investigative Ophthalmology & Visual Science·Robert F MullinsEdwin M Stone
Jul 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Emeline F NandrotSilvia C Finnemann
Aug 19, 2007·Archives of Ophthalmology·Camiel J F BoonCarel B Hoyng
Feb 1, 2008·Journal of Peptide Science : an Official Publication of the European Peptide Society·R AbesB Lebleu
Apr 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Houbin ZhangWolfgang Baehr
Jul 5, 2008·Investigative Ophthalmology & Visual Science·Birgit LorenzT Michael Redmond
Jul 10, 2008·Journal of Medical Genetics·R BurgessF D C Manson
Sep 4, 2008·Ophthalmic Genetics·Robert K Koenekoop
Oct 3, 2008·PLoS Biology·Vanessa M LopezBrian S McKay

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Citations

Apr 3, 2009·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M A GamulescuH Helbig
Mar 2, 2016·Der Nervenarzt·P P Urban, J Höltje

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