Genetic disruption of cyclooxygenase-2 does not improve histological or behavioral outcome after traumatic brain injury in mice.

Journal of Neuroscience Research
Muzamil AhmadSteven H Graham

Abstract

Increasing evidence suggests a role for cyclooxygenase-2 (COX-2) in traumatic brain injury (TBI). In the present study, the role of COX-2 in TBI was investigated using COX-2 gene-disrupted (COX-2 null) mice and wild-type (WT) controls that were subjected to the controlled cortical impact (CCI) model of TBI. There was increased expression of COX-2 in ipsilateral hippocampus in WT mice subjected to CCI. CCI resulted in a significant increase in prostaglandin E(2) concentrations in WT compared with COX-2 null hippocampi. There was a significant increase in TUNEL staining of CA1 neurons 24 hr after CCI in WT, but not in COX-2 null mice, compared with sham-operated controls, which is consistent with a protective role for COX-2 in the early phase of injury after TBI. However, there was no difference in lesion volume 21 days after CCI in COX-2 null and WT mice. COX-2 gene disruption did not alter Morris water maze performance. Taken together, these results suggest only a minor role for COX-2 activity in determining outcome after TBI in mouse.

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Nov 1, 1988·Stroke; a Journal of Cerebral Circulation·T SasakiK Takakura
May 23, 1998·Annual Review of Pharmacology and Toxicology·J R VaneR M Botting
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·M NakayamaS H Graham
Aug 24, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M J WhalenP M Kochanek
Nov 30, 2000·Neuroreport·K M FrickJ Berger-Sweeney
Feb 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·C IadecolaM E Ross
Feb 21, 2002·Journal of Neurotrauma·Sean D HurleyM Kerry O'Banion
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Peter TeismannSerge Przedborski
Oct 7, 2003·Neuromolecular Medicine·Douglas H SmithTracy K McIntosh
Feb 28, 2004·Expert Reviews in Molecular Medicine·Orina Belton, Desmond J Fitzgerald
Sep 15, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kon ChuJae-Kyu Roh
Nov 25, 2004·Neuroscience·A W UnterbergK L Kiening
Dec 22, 2005·Nature Immunology·Charles N Serhan, John Savill
Dec 27, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·ShouWei Han, Jesse Roman
Jan 18, 2006·Nature Medicine·Fabiana S MachadoJulio Aliberti
Apr 26, 2006·European Journal of Clinical Investigation·B T LarsenO A Hatoum
Jun 6, 2006·Current Opinion in Pharmacology·Jan M Schwab, Charles N Serhan
Jul 13, 2006·Brain : a Journal of Neurology·Katsuichi MiyamotoTakashi Yamamura
Feb 3, 2007·Genome Biology·Christopher D ToscanoFrancesca Bosetti
Apr 19, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Wenri ZhangNabil J Alkayed
Jul 12, 2007·Pediatric Research·Robert W HickeySteven H Graham
Sep 6, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yichen LaiRobert S B Clark
Sep 11, 2007·Apoptosis : an International Journal on Programmed Cell Death·Sévan KaloustianGuy Rousseau

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Citations

Mar 10, 2009·Trends in Pharmacological Sciences·Sang-Ho ChoiFrancesca Bosetti
Mar 1, 2012·Journal of Neurochemistry·Jonathan D VerrierEdwin K Jackson
Mar 1, 2012·Respiratory Physiology & Neurobiology·Hung-Fu LeeYu Ru Kou
May 10, 2018·Scientific Reports·Travis C JacksonPatrick M Kochanek
Feb 7, 2020·Journal of Neurotrauma·Chaitanya InampudiPeter J Crack
Mar 17, 2018·Neuroscience and Biobehavioral Reviews·Laura B TuckerJoseph T McCabe
Jun 25, 2018·Neurobiology of Disease·Patricia G SalettiAristea S Galanopoulou

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