Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

Nature Genetics
E Lander, L Kruglyak

Abstract

Genetic studies are under way for many complex traits, spurred by the recent feasibility of whole genome scans. Clear guidelines for the interpretation of linkage results are needed to avoid a flood of false positive claims. At the same time, an overly cautious approach runs the risk of causing true hints of linkage to be missed. We address this problem by proposing specific standards designed to maintain rigor while also promoting communication.

References

Jan 1, 1992·Cytogenetics and Cell Genetics·J D Terwilliger, J Ott
Oct 1, 1984·Annals of Human Genetics·J Chotai
Jun 1, 1994·Nature Genetics·G GyapayJ Weissenbach
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·J A Todd
Jul 3, 1995·American Journal of Medical Genetics·Y YuvalM Pras
Mar 1, 1995·Genetics·L Kruglyak, E S Lander
Oct 1, 1994·Nature Genetics·G Thomson
Sep 30, 1994·Science·E S Lander, N J Schork
Apr 29, 1998·American Journal of Human Genetics·N E Morton
Mar 11, 2000·American Journal of Human Genetics·S C PrattL Kruglyak
May 29, 2003·Human Heredity·James D MalleyJoan E Bailey-Wilson

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Citations

Nov 13, 2008·Archives of Neurology·Joseph H LeeUNKNOWN National Institute on Aging Late-Onset Alzheimer's Disease Family Study Group
Jan 11, 2007·Archives of Ophthalmology·Priya DuggalJoan E Bailey-Wilson
Jul 9, 2008·Archives of General Psychiatry·Peter P ZandiUNKNOWN National Institute of Mental Health Genetics Initiative Bipolar Disorder Consortium
Jul 28, 2011·JAMA : the Journal of the American Medical Association·Mohammed OrloffCharis Eng
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Oct 16, 1999·International Journal of Cancer. Journal International Du Cancer·H SzymanskaP Demant
Oct 19, 1999·Statistics in Medicine·J M OlsonR C Elston
Jan 29, 2000·Statistics in Medicine·J S WitteL R Cardon
Aug 1, 1997·Genes, Chromosomes & Cancer·E A HollandG J Mann
Oct 22, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M Brahic, J F Bureau
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·B ChangJ Xu
Mar 10, 2001·Diabetes/metabolism Research and Reviews·Y Park, G S Eisenbarth
Apr 29, 1998·Arthritis and Rheumatism·M A BrownB P Wordsworth
Jul 21, 2000·Arthritis and Rheumatism·E SusolJ Worthington
Jan 31, 2002·Arthritis and Rheumatism·Peter OlofssonRikard Holmdahl
Sep 28, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Mari A KaunistoMaija Wessman
Sep 25, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Benjamin M NealeKenneth S Kendler
Apr 16, 2002·Arthritis and Rheumatism·S DemissieD T Felson
Sep 7, 2001·Diabetes/metabolism Research and Reviews·R L HansonW C Knowler
Dec 22, 1999·Genetic Epidemiology·C AragakiL P Zhao
Dec 22, 1999·Genetic Epidemiology·D M MandalJ E Bailey-Wilson
Dec 22, 1999·Genetic Epidemiology·M NicolaouL A Cupples
Dec 22, 1999·Genetic Epidemiology·K WangJ Huang
Dec 22, 1999·Genetic Epidemiology·H K TiwariV George
Dec 22, 1999·Genetic Epidemiology·A M ValdesG Thomson

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