Genetic dissection of neural circuits underlying sexually dimorphic social behaviours

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Daniel W Bayless, Nirao M Shah

Abstract

The unique hormonal, genetic and epigenetic environments of males and females during development and adulthood shape the neural circuitry of the brain. These differences in neural circuitry result in sex-typical displays of social behaviours such as mating and aggression. Like other neural circuits, those underlying sex-typical social behaviours weave through complex brain regions that control a variety of diverse behaviours. For this reason, the functional dissection of neural circuits underlying sex-typical social behaviours has proved to be difficult. However, molecularly discrete neuronal subpopulations can be identified in the heterogeneous brain regions that control sex-typical social behaviours. In addition, the actions of oestrogens and androgens produce sex differences in gene expression within these brain regions, thereby highlighting the neuronal subpopulations most likely to control sexually dimorphic social behaviours. These conditions permit the implementation of innovative genetic approaches that, in mammals, are most highly advanced in the laboratory mouse. Such approaches have greatly advanced our understanding of the functional significance of sexually dimorphic neural circuits in the brain. In this review, we...Continue Reading

References

Apr 15, 1976·Nature·B Svare, R Gandelman
May 1, 1975·The Journal of Comparative Neurology·F Scalia, S S Winans
Jan 1, 1975·Physiology & Behavior·T J La Vaque, C H Rodgers
Jan 1, 1992·Annual Review of Neuroscience·M Davis
Oct 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·C J Wysocki, J J Lepri
Apr 2, 1986·Brain Research·A C HennesseyD A Edwards
Aug 20, 1971·Science·G Raisman, P M Field
Jun 1, 1969·Archives of Neurology·A G Reeves, F Plum
Mar 20, 1981·The Journal of Comparative Neurology·G A Kevetter, S S Winans
Mar 20, 1981·The Journal of Comparative Neurology·G A Kevetter, S S Winans
Jul 1, 1984·Brain Research Bulletin·D Commins, P Yahr
Jan 1, 1994·Psychoneuroendocrinology·M M McCarthy
Dec 15, 1995·Cell·D J MangelsdorfR M Evans
Jan 1, 1996·Progress in Brain Research·M T ShipleyM M Behbehani
Dec 1, 1996·Endocrine Reviews·M Beato, A Sánchez-Pacheco
Jan 15, 1997·Annals of the New York Academy of Sciences·S W NewmanS Kollack-Walker
Jan 1, 1997·Brain Research Bulletin·A Guillamón, S Segovia
Jun 3, 1998·Methods : a Companion to Methods in Enzymology·B Sauer
Jun 25, 1998·Behavioural Brain Research·J G Veening, L M Coolen
Nov 25, 1998·Biochemical and Biophysical Research Communications·S HondaS Maeda
Feb 4, 1999·Annals of the New York Academy of Sciences·M Meredith
Jan 29, 2000·The European Journal of Neuroscience·H von Campenhausen, K Mori
May 16, 2000·Brain Research Bulletin·D Schulz, R S Canbeyli
Dec 20, 2000·Brain Research·L W Swanson
Apr 18, 2001·Brain Research·S C Gammie, R J Nelson
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Bradley G LeypoldRichard Axel
May 2, 2003·Annals of the New York Academy of Sciences·Larry W Swanson

❮ Previous
Next ❯

Citations

Feb 3, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Margaret M McCarthy
Oct 19, 2016·Nature Reviews. Neuroscience·David J Anderson
Sep 19, 2017·Nature Neuroscience·Koichi HashikawaDayu Lin
May 26, 2017·Physiological Reviews·Paul S CookeRex A Hess
Aug 1, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David R Rubinow, Peter J Schmidt
Jun 5, 2020·International Journal of Molecular Sciences·Diana LupuJoëlle Rüegg
Mar 23, 2019·Proceedings of the National Academy of Sciences of the United States of America·Liching LoBrandon Weissbourd
Feb 8, 2021·Journal of Neuroscience Research·Gabriele MasiPaola Brovedani
Feb 13, 2021·The Journal of Comparative Neurology·Da-Jiang ZhengSteven M Phelps
Feb 19, 2021·PLoS Genetics·Margarita V BrovkinaE Josephine Clowney
Nov 6, 2018·Neuroscience Research·Kentaro K Ishii, Kazushige Touhara
Feb 27, 2021·Frontiers in Behavioral Neuroscience·William J Giardino, Matthew B Pomrenze
Nov 30, 2019·Hormones and Behavior·Kristen DelevichLinda Wilbrecht

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.