Genetic diversity and antigenic polymorphism in Plasmodium falciparum: extensive serological cross-reactivity between allelic variants of merozoite surface protein 2.

Infection and Immunity
Simon FranksEleanor Riley

Abstract

Diversity in the surface antigens of malaria parasites is generally assumed to be a mechanism for immune evasion, but there is little direct evidence that this leads to evasion of protective immunity. Here we show that alleles of the highly polymorphic merozoite surface protein 2 (MSP-2) can be grouped (within the known dimorphic families) into distinct serogroups; variants within a serogroup show extensive serological cross-reactivity. Cross-reactive epitopes are immunodominant, and responses to them may be boosted at the expense of responses to novel epitopes (original antigenic sin). The data imply that immune selection explains only some of the diversity in the msp-2 gene and that MSP-2 vaccines may need to include only a subset of the known variants in order to induce pan-reactive antibodies.

References

Mar 1, 1991·Immunology Today·K P Day, K Marsh
Mar 1, 1990·Molecular and Biochemical Parasitology·J A SmytheR F Anders
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M F GoodL H Miller
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A A LalT F McCutchan
Apr 1, 1995·Molecular and Biochemical Parasitology·M K Hughes, A L Hughes
May 1, 1996·Molecular Biology and Evolution·T EndoT Gojobori
Aug 22, 2000·Parasitology Today·S M RichF J Ayala
Dec 15, 2000·Trends in Ecology & Evolution·Z Yang, J P Bielawski
Apr 12, 2001·Annals of Tropical Medicine and Parasitology·E H HoffmannM U Ferreira
Jan 1, 1994·Parasitology Today·S Gupta, K P Day

❮ Previous
Next ❯

Citations

May 17, 2005·Immunogenetics·Bjoern PetersAlessandro Sette
Apr 23, 2004·Trends in Cell Biology·Neil D Perkins
Mar 23, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·M R RanjitG P Chhotray
Sep 6, 2000·Trends in Biochemical Sciences·N D Perkins
Oct 27, 2004·Infection and Immunity·Christian FlückIngrid Felger
Nov 10, 2009·BMC Bioinformatics·Adaoha E C IhekwabaCorrado Priami
Sep 12, 2003·BMC Molecular Biology·Sonia RochaNeil D Perkins
May 20, 2009·Journal of Neuroinflammation·Xianrong R MaoSteven W Barger
Mar 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·C J DrakeleyE M Riley
Jan 26, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Aarti PatilMarcelo U Ferreira
Aug 12, 2004·Tropical Medicine & International Health : TM & IH·M R RanjitA S Acharya
Sep 22, 2007·Journal of Peptide Science : an Official Publication of the European Peptide Society·Xiaodong YangRaymond S Norton
Sep 24, 2004·Molecular and Biochemical Parasitology·Gajinder Pal SinghAmit Sharma
Nov 9, 2007·Trends in Parasitology·Patrick CorranChris Drakeley
Jun 12, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Madhumita BasuSanghamitra Sengupta
Nov 13, 2004·Clinical and Diagnostic Laboratory Immunology·Marcelo U FerreiraGerhard Wunderlich

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.