Genetic diversity and correlation with feline infectious peritonitis of feline coronavirus type I and II: a 5-year study in Taiwan.

Veterinary Microbiology
Chao-Nan LinLing-Ling Chueh

Abstract

The outcomes of feline coronavirus (FCoV) infection vary greatly from asymptomatic or mild enteric infection to fatal feline infectious peritonitis (FIP). On the basis of in vitro neutralization tests, FCoVs can be divided into two serotypes. To explore the correlation between different types of FCoV and FIP, clinical specimens collected from 363 naturally infected cats during 2003-2007 were analyzed. Amplification of a portion of the S gene from the FCoV was performed and a total of 222 cases were differentiated. Among them, 197 (88.7%) cats were type I-positive, 13 (5.9%) were type II-positive, and 12 (5.4%) were positive for both types. Irrespective of the predominance of type I FCoV infection in Taiwan, type II FCoV demonstrated a significantly higher correlation with FIP (p<0.01). Analysis of partial S gene sequences of the local type I and II FCoVs strains revealed that type I viruses were more genetically divergent (6.2-11.7%) than type II viruses (0.6-3.2%) within the 5-year study period. The higher genetic diversity of type I FCoVs might be due to the larger infected cat population and to the long period of viral persistence in asymptomatic cats in comparison to type II viruses.

References

Feb 15, 1992·The Veterinary Record·D D Addie, O Jarrett
Jun 1, 1992·The Journal of Veterinary Medical Science·T HohdatsuH Koyama
Jul 11, 1992·The Veterinary Record·A H SparkesD A Harbour
Oct 9, 1999·Veterinary Microbiology·H Vennema
May 22, 2003·Journal of Virological Methods·Annamaria PratelliCanio Buonavoglia
Sep 19, 2003·The Journal of General Virology·D D AddieO Jarrett
Dec 9, 2003·Journal of Veterinary Internal Medicine·Katrin HartmannWalter Hermanns
Oct 8, 2005·Clinical and Diagnostic Laboratory Immunology·Maya KummrowHans Lutz
Feb 3, 2007·Journal of Virology·D VijaykrishnaY Guan

❮ Previous
Next ❯

Citations

Aug 17, 2014·Research in Veterinary Science·C M Borschensky, M Reinacher
Sep 29, 2011·Virology Journal·Dong-Jun AnBong-Kyun Park
May 31, 2013·The Journal of Veterinary Medical Science·Takehisa SomaTomoko Tajima
Dec 15, 2012·Virus Genes·Chao-Nan LinLing-Ling Chueh
Oct 31, 2015·Archives of Virology·Tomomi TakanoTsutomu Hohdatsu
Mar 20, 2010·The Journal of General Virology·Anja KiparHans Lutz
Apr 19, 2015·BMC Veterinary Research·Yoshikazu TanakaTomohiro Yamaguchi
Aug 6, 2013·Veterinary Microbiology·Dominique A J OlyslaegersHans J Nauwynck
Feb 27, 2014·Veterinary Pathology·A Kipar, M L Meli
Sep 5, 2019·The Journal of General Virology·Delphine D AcarHans J Nauwynck
Aug 29, 2021·Viruses·Chao-Nan LinPeck Toung Ooi
Nov 23, 2012·Virology Journal·Alazawy AmerTengku Ibrahim Tengku Azmi

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

DNASTAR MegAlign
MegAlign
DNASTAR
Clustal W

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.