Genetic diversity and haplotype structure of 21 Y-STRs, including nine noncore loci, in South Tunisian Population: Forensic relevance

Electrophoresis
Faten Makki-RmidaSaber Masmoudi

Abstract

Y chromosome STRs (Y-STRs) are being used frequently in forensic laboratories. Previous studies of Y-STR polymorphisms in different groups of the Tunisian population identified low levels of diversity and discrimination capacity (DC) using various commercial marker sets. This definitely limits the use of such systems for Y-STRs genotyping in Tunisia. In our investigation on South Tunisia, 200 unrelated males were typed for the 12 conventional Y-STRs included in the PowerPlex® Y System. Additional set of nine noncore Y-STRs including DYS446, DYS456, DYS458, DYS388, DYS444, DYS445, DYS449, DYS710, and DYS464 markers were genotyped and evaluated for their potential in improving DC. Allele frequency, gene diversity, haplotype diversity (HD), and DC calculation revealed that DYS464 was the most diverse marker followed by DYS710 and DYS449 markers. The standard panel of 12 Y-STRs (DC = 80.5%) and the nine markers were combined to obtain DC of 99%. Among the 198 different haplotypes observed, 196 haplotypes were unique (HD = 99.999). Out of the nine noncore set, six Y-STRs (DYS458, DYS456, DYS449, DYS710, DYS444, and DYS464) had the greatest impact on enhancing DC. Our data provided putative Y-STRs combination to be used for genetic a...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Jan 1, 1997·International Journal of Legal Medicine·M A JoblingC Tyler-Smith
Sep 17, 2002·Forensic Science International : Synergy·John M ButlerMichael F Hammer
Dec 13, 2002·Forensic Science International : Synergy·Alan J ReddMichael F Hammer
Aug 21, 2003·Forensic Science International : Synergy·C Brandt-CasadevallP Mangin
Nov 12, 2003·Forensic Science International : Synergy·Burkhard BergerWalther Parson
Mar 26, 2004·Forensic Science International : Synergy·Richard SchoskeJohn M Butler
Jun 9, 2005·Forensic Science International : Synergy·Lotfi CherniAmel BenAmmar Elgaaied
Jul 12, 2005·Forensic Science International : Synergy·Sabeh FrigiAmel El Gaaied
Nov 18, 2005·Forensic Science International : Synergy·Emma J ParkinMark A Jobling
Nov 19, 2005·Forensic Science International : Synergy·Imen AyadiAhmed Rebai
Jan 18, 2006·Forensic Science International : Synergy·John M ButlerMargaret C Kline
Feb 7, 2006·Forensic Science International : Synergy·Yuet Meng ChangDaniel L C Kuehn
Sep 1, 2006·Forensic Science International : Synergy·Neil LeatSean Davison
Sep 30, 2006·Forensic Science International : Synergy·Long Li KangYuming Ma
Mar 14, 2007·Forensic Science International : Synergy·Natsuko MizunoKentaro Kasai
Feb 5, 2010·Forensic Science International. Genetics·María Eugenia D'AmatoSean Davison
May 12, 2010·Forensic Science International. Genetics·Verónica GomesLeonor Gusmão
May 14, 2011·Molecular Ecology Resources·Laurent Excoffier, Heidi E L Lischer
May 27, 2011·Forensic Science International. Genetics·Kaye N BallantyneManfred Kayser
Aug 5, 2011·Journal of Cardiovascular Disease Research·Wenbo ZhangRuth B Caldwell
Sep 15, 2011·American Journal of Physical Anthropology·Karima Fadhlaoui-ZidDavid Comas
Nov 20, 2012·Electrophoresis·Karima Fadhlaoui-ZidAmel Benammar-Elgaaied
Jun 12, 2014·Human Mutation·Kaye N BallantyneManfred Kayser
Dec 10, 2014·Forensic Science International. Genetics·Urszula RogallaTomasz Grzybowski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.