Abstract
Streptococcus suis is a serious threat to swine industry and public health. In this work, a total of 62 S. suis isolates recovered from infected and healthy pigs from four provinces in northern China were classified by multilocus sequence typing into nine sequence types (STs), including six novel ones, namely, ST417, ST418, ST419, ST420, ST421, and ST422. The majority (64.5%) of these 62 isolates belong to serotype 2; all of these serotype 2 isolates can be assigned into ST1 or ST28 clonal complex, indicating at least two parallel routes of clonal dissemination of these isolates. In these serotype 2 isolates, 23 (20 from healthy pigs and three from diseased pigs) were identified as ST7 strains, which were previously characterized as the cause of streptococcal toxic shock-like syndrome. The novel ST strains lack 89 K pathogenicity island but can cause septicemia and meningitis in a mouse model, showing remarkable differences in virulence. The ST421 strain named HLB causes suppurative encephalitis. Our results highlighted the need for increased surveillance of S. suis in farm-raised pigs in northern China.
References
Jul 1, 1990·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·R Higgins, M Gottschalk
Jul 1, 1995·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·R HigginsJ Henrichsen
May 1, 1995·Infection and Immunity·S QuessyR Higgins
Mar 20, 2001·Infection and Immunity·A G AllenD Maskell
Nov 29, 2001·Bioinformatics·M S ChanB G Spratt
Jan 30, 2002·Journal of Comparative Pathology·L W MadsenH E Jensen
Aug 1, 2002·Journal of Clinical Microbiology·Henk J WisselinkHilde E Smith
Oct 2, 2002·Journal of Clinical Microbiology·Samantha J KingAdrian M Whatmore
May 29, 2003·FEMS Microbiology Letters·Roni S AdiriEliora Z Ron
Feb 20, 2004·Journal of Bacteriology·Edward J FeilBrian G Spratt
Mar 23, 2004·Nucleic Acids Research·Robert C Edgar
Jul 27, 2005·Journal of Molecular Evolution·Paul FearnheadNigel French
Apr 6, 2006·PLoS Medicine·Jiaqi TangGeorge F Gao
May 19, 2006·Emerging Infectious Diseases·Hongjie YuUNKNOWN Streptococcus suis study groups
Sep 13, 2006·Emerging Infectious Diseases·Changyun YeJianguo Xu
Mar 22, 2007·PloS One·Chen ChenJun Yu
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·María C Domínguez-PunaroMarcelo Gottschalk
May 8, 2008·PloS One·Ming LiJiaqi Tang
Nov 20, 2008·The Journal of Infectious Diseases·Mariela Segura
Jan 20, 2011·Molecular Microbiology·Ming LiGeorge F Gao
Dec 17, 2011·Emerging Infectious Diseases·Nahuel FittipaldiMarcelo Gottschalk
Dec 12, 2012·Current Microbiology·Kaicheng WangBaoxu Huang
Aug 21, 2013·PloS One·Zhijie LiuJianguo Xu
Citations
Oct 6, 2015·Case Reports in Infectious Diseases·Marianneta ChatzopoulouMaria Tsiakalou
Jul 21, 2016·PloS One·Mari TohyaTsutomu Sekizaki
Mar 7, 2021·Pathogens·Shujie WangXuehui Cai