Genetic diversity at neutral and adaptive loci determines individual fitness in a long-lived territorial bird.

Proceedings. Biological Sciences
Rosa AgudoJosé Antonio Donázar

Abstract

There is compelling evidence about the manifest effects of inbreeding depression on individual fitness and populations' risk of extinction. The majority of studies addressing inbreeding depression on wild populations are generally based on indirect measures of inbreeding using neutral markers. However, the study of functional loci, such as genes of the major histocompatibility complex (MHC), is highly recommended. MHC genes constitute an essential component of the immune system of individuals, which is directly related to individual fitness and survival. In this study, we analyse heterozygosity fitness correlations of neutral and adaptive genetic variation (22 microsatellite loci and two loci of the MHC class II, respectively) with the age of recruitment and breeding success of a decimated and geographically isolated population of a long-lived territorial vulture. Our results indicate a negative correlation between neutral genetic diversity and age of recruitment, suggesting that inbreeding may be delaying reproduction. We also found a positive correlation between functional (MHC) genetic diversity and breeding success, together with a specific positive effect of the most frequent pair of cosegregating MHC alleles in the popula...Continue Reading

References

Nov 29, 1994·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·L GustafssonA Qvarnström
Sep 26, 2001·Proceedings. Biological Sciences·W AmosT Coulson
Nov 28, 2002·Molecular Ecology·Bengt Hansson, Lars Westerberg
Oct 16, 2003·Comptes rendus biologies·Richard Frankham
Nov 26, 2003·Journal of Evolutionary Biology·L Bernatchez, C Landry
Sep 16, 2004·Molecular Ecology·F BallouxT Coulson
Feb 9, 2005·Evolution; International Journal of Organic Evolution·Camille BonneaudGabriele Sorci
Aug 12, 2005·Heredity·S B Piertney, M K Oliver
Mar 30, 2006·Heredity·M J Donnelly
Sep 19, 2006·Current Biology : CB·Jon Slate, Josephine Pemberton
Nov 17, 2006·Molecular Ecology·J M AparicioP J Cordero
Jun 15, 2007·Molecular Ecology·Patrice DavidJérôme Goudet
Feb 14, 2008·Biology Letters·Gordon LuikartMichael K Schwartz
Nov 11, 2008·Environmental Pollution·Laura GangosoJosé Antonio Donázar
Nov 27, 2008·Proceedings. Biological Sciences·Martin KalbeManfred Milinski
Jan 22, 2009·Evolution; International Journal of Organic Evolution·Anne Da SilvaGordon Luikart
Feb 18, 2009·Evolution; International Journal of Organic Evolution·Lutz FromhageJane M Reid
May 28, 2009·Archives of Pharmacal Research·Warunee JirawattanapongChamnan Patarapanich
Jan 15, 2010·Proceedings. Biological Sciences·Lewis G Spurgin, David S Richardson
Feb 4, 2010·BMC Evolutionary Biology·Donald BlomqvistLars-Ake Flodin
Feb 13, 2010·Evolution; International Journal of Organic Evolution·Marta SzulkinPatrice David
Jul 14, 2010·Molecular Ecology·Kirsty WorleyDavid S Richardson
Dec 15, 2010·BMC Evolutionary Biology·Rosa AgudoJosé Antonio Donázar
Jan 1, 2009·Language Learning and Development : the Official Journal of the Society for Language Development·Daniel J WeissAaron D Mitchel
Mar 1, 2010·Biological Conservation·Jacek RadwanWiesław Babik

❮ Previous
Next ❯

Citations

Jan 5, 2014·PloS One·Ross L GoldingayBrendan D Taylor
Jun 5, 2013·Evolution; International Journal of Organic Evolution·Jonathan L Richardson, Mark C Urban
Dec 4, 2015·Proceedings. Biological Sciences·Isabel Rodríguez-QuilónSantiago C González-Martínez
Jan 30, 2015·Molecular Ecology·Alberto VelandoPaloma Moran
Jul 10, 2016·Molecular Ecology·Sozos N MichaelidesTobias Uller
Nov 20, 2020·Animals : an Open Access Journal From MDPI·Marina García-AlfonsoJosé A Donázar
May 25, 2021·The Journal of Animal Ecology·Joanna Drzewińska-ChańkoPiotr Minias

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.