Genetic diversity, clonality and sexuality in Toxoplasma gondii

International Journal for Parasitology
Daniel AjzenbergMarie-Laure Dardé

Abstract

The majority of Toxoplasma gondii strains from a variety of human and animal sources have been grouped into three highly clonal but closely related lineages. The low occurrence of nucleotide differences among the three predominant lineages and their unusual dimorphic allelic composition suggest that they have arisen from a recent common ancestry. Less than 1% of the previously studied strains contain unique genotypes and high divergence of DNA sequence, and therefore are considered 'exotic' or 'atypical' strains. The seemingly low genetic diversity in T. gondii may have been underestimated because most parasite strains in previous studies were collected from human patients and domestic animals in North America and Europe. To investigate the genetic diversity of T. gondii, we analysed parasite strains isolated from remote geographical regions by multilocus microsatellite sequencing and phylogenetic analysis. The genetic diversity indices, the molecular analysis of microsatellite genotypes and the constructed phylogram considered together suggest that the global T. gondii population is highly diversified and not characteristic of a clonal organism. The most parsimonious hypothesis is that T. gondii presents a complex population s...Continue Reading

References

Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M TibayrencF J Ayala
Jan 1, 1980·Memórias do Instituto Oswaldo Cruz·J J Ferraroni, M C Marzochi
Dec 1, 1995·The Journal of Infectious Diseases·D K Howe, L D Sibley
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·D B GoldsteinM W Feldman
Nov 18, 1998·Journal of Clinical Microbiology·P BossiF Bricaire
Nov 27, 1999·International Journal for Parasitology·A L BanũlsM Tibayrenc
Dec 29, 2000·The Journal of Parasitology·T LehmannJ P Dubey
Feb 13, 2001·Journal of Microbiological Methods·X ZhaoE S Loker
Jul 28, 2001·The Journal of Infectious Diseases·M E GriggT P Margolis
Jan 10, 2002·The Journal of Parasitology·C R BlackstonT Lehmann
Feb 14, 2002·International Journal for Parasitology·Daniel AjzenbergMarie Laure Dardé
Aug 31, 2002·Journal of Clinical Microbiology·Béatrice BulleRenaud Piarroux
Nov 1, 2002·Journal of Clinical Microbiology·B CarmeM L Dardé
Apr 12, 2003·BMC Bioinformatics·Nelson D Young, John Healy
Jun 6, 2003·Microbes and Infection·Michael E Grigg, Yasuhiro Suzuki
Jun 18, 2003·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Tovi LehmannJ P Dubey
Sep 18, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jade GhosnChristine Katlama
Nov 25, 2003·The Journal of Parasitology·J P DubeyT Lehmann
Nov 25, 2003·The Journal of Parasitology·C B L GaussJ P Dubey
Jan 20, 2004·Veterinary Parasitology·C SreekumarJ P Dubey
May 26, 2004·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Tovi LehmannJ P Dubey

❮ Previous
Next ❯

Citations

May 29, 2007·Parasitology Research·Aurélien Dumètre, Marie-Laure Dardé
Nov 26, 2010·Parasitology Research·Ana Patrícia LopesLuís Cardoso
Sep 29, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A LassP Myjak
Oct 31, 2012·Journal of Biosciences·Emily L Clark, Damer P Blake
Oct 2, 2013·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology· Vikrant SudanM Sankar
Jul 31, 2013·International Journal for Parasitology·R C Andrew Thompson
Oct 15, 2013·The Journal of Infection·Florence Robert-Gangneux
Apr 30, 2013·Theoretical Population Biology·Matthew TurnerXiaopeng Zhao
Jul 16, 2010·Transactions of the Royal Society of Tropical Medicine and Hygiene·Daniel Ajzenberg
Jun 15, 2011·The Journal of Experimental Medicine·Masahiro YamamotoKiyoshi Takeda
Jul 24, 2013·The Journal of Infectious Diseases·Leila ShobabMichael E Grigg
Aug 19, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·L David SibleyBenjamin M Rosenthal
Mar 6, 2012·Applied and Environmental Microbiology·Rosanna DrumoSimone M Cacciò
Apr 12, 2012·Clinical Microbiology Reviews·Florence Robert-Gangneux, Marie-Laure Dardé
Jul 20, 2007·Journal of Clinical Microbiology·Séverine GenotStéphane Ranque
Oct 1, 2010·Journal of Clinical Microbiology·Daniel AjzenbergMarie-Laure Dardé
Jan 4, 2013·Journal of Clinical Microbiology·Ana Carolina Aguiar Vasconcelos CarneiroRicardo Wagner Almeida Vitor
Apr 9, 2005·Journal of Clinical Microbiology·Daniel AjzenbergMarie-Laure Dardé
Jul 25, 2006·Archives of Disease in Childhood·R Gilbert, C Dezateux
Mar 6, 2008·PLoS Neglected Tropical Diseases·Ernest J MuiRima McLeod
Aug 14, 2008·PLoS Neglected Tropical Diseases·Ruth E GilbertUNKNOWN European Multicentre Study on Congenital Toxoplasmosis (EMSCOT)
Nov 13, 2010·PLoS Neglected Tropical Diseases·Aurélien MercierMarie-Laure Dardé
Oct 8, 2011·PLoS Neglected Tropical Diseases·Eileen StillwaggonRima McLeod
Dec 17, 2010·The Journal of Parasitology·Y M Al-KappanyJ P Dubey
May 27, 2011·The Journal of Parasitology·C Alvarado-EsquivelJ P Dubey
Apr 25, 2006·The Journal of Parasitology·J P DubeyP Thulliez
Apr 25, 2006·The Journal of Parasitology·J P DubeyT Lehmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amoebiasis

Amoebiasis, infection by the protozoan parasite Entamoeba histolytica, remains a global health problem, despite the availability of effective treatment. Here is the latest research.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Tovi LehmannJ P Dubey
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
M DemarB Carme
© 2021 Meta ULC. All rights reserved