Genetic diversity in the Block 2 region of the merozoite surface protein 1 (MSP-1) of Plasmodium falciparum: additional complexity and selection and convergence in fragment size polymorphism

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Shannon TakalaAltaf A Lal

Abstract

Fragment size in the Block 2 repetitive region of merozoite surface protein 1 (MSP1) has commonly been used as a molecular marker in studies of malaria transmission dynamics and host immunity in Plasmodium falciparum malaria. In this study, we further explore the genetic variation in MSP-1 Block 2 underlying potential problems faced while studying the immune responses elicited by this vaccine target and while using it as a molecular marker in epidemiologic investigations. We describe the distribution of a new Block 2 recombinant allele family in samples collected from western Kenya and other malarious regions of the world and provide evidence that this allele family is found worldwide and that all MR alleles most likely originated from a single recombination event. We test whether the number of tandem repeats (i.e. fragment size) can be considered neutral in an area of high transmission in western Kenya. In addition, we investigate the validity of the assumption that Block 2 alleles of the same size and allele family are identical by examining MSP1 Block 2 amino acid sequences obtained from full-length MSP-1 clones generated from infected Kenyan children and find that this assumption does not hold. We conclude that the worldwid...Continue Reading

References

Apr 1, 1978·Theoretical Population Biology·G A Watterson, J Perlow
Jan 1, 1992·Memórias do Instituto Oswaldo Cruz·A A HolderS Shai
Jan 1, 1992·Molecular and Biochemical Parasitology·T F McCutchanA P Waters
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M TibayrencF J Ayala
Mar 1, 1991·The American Journal of Tropical Medicine and Hygiene·S JongwutiwesH Kanbara
May 20, 1987·Journal of Molecular Biology·K TanabeJ G Scaife
Mar 1, 1972·Theoretical Population Biology·W J Ewens
May 1, 1993·Molecular and Biochemical Parasitology·L H MillerT F McCutchan
Nov 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·F RobertO Mercereau-Puijalon
Feb 1, 1997·The American Journal of Tropical Medicine and Hygiene·H A BabikerD Walliker
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·S M RichF J Ayala
Mar 21, 1998·The American Journal of Tropical Medicine and Hygiene·R E PaulK P Day
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·D J ConwayB M Greenwood
Sep 2, 1999·Tropical Medicine & International Health : TM & IH·T JelinekT Löscher
Feb 16, 2000·The American Journal of Tropical Medicine and Hygiene·F ArieyT Fandeur
May 18, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·A FärnertV E do Rosario
Jul 13, 2004·Trends in Parasitology·Ananias A EscalanteAltaf A Lal

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Citations

Nov 28, 2012·Malaria Journal·Ana Cecilia LopezGustavo A Fontecha
Jan 25, 2014·Malaria Journal·Mohamed Salem O Ahmedou SalemAli O Mohamed Salem O Boukhary
Nov 15, 2011·Tropical Medicine & International Health : TM & IH·Kwami L AwagaSabiba K E Amouzou
Apr 26, 2016·Journal of Parasitology Research·William YavoMarielle K Bouyou-Akotet
Sep 2, 2015·The Korean Journal of Parasitology·Denise Patricia Mawili-MboumbaMarielle Karine Bouyou-Akotet
Apr 18, 2014·Journal of Immunology Research·Leidiane Amorim SoaresPaulo Afonso Nogueira
Apr 29, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Bita BordbarAudrey Sabbagh
Apr 14, 2010·PLoS Pathogens·Melissa R van DijkChris J Janse
Jun 5, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Pabitra SahaArdhendu K Maji
May 15, 2009·PloS One·Kevin K A TettehDavid J Conway
Oct 3, 2006·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·M Andreina PachecoAnanias A Escalante
Apr 2, 2005·Protein Expression and Purification·Aditi GuptaAdrian H Batchelor
Aug 12, 2015·The American Journal of Tropical Medicine and Hygiene·Ananias A EscalanteIngrid Felger
Jan 12, 2016·PLoS Neglected Tropical Diseases·M Andreína PachecoAnanias A Escalante
Sep 10, 2014·The Journal of Parasitology·Dante S ZarlengaGiuseppe Nascetti
Jun 15, 2007·Memórias do Instituto Oswaldo Cruz·Wanessa Christina de Souza-NeirasRicardo Luiz Dantas Machado
Jan 2, 2021·Malaria Journal·Bui Van LongThirumalaisamy P Velavan
Aug 11, 2019·Microbiology Spectrum·Ananias A Escalante, M Andreína Pacheco

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