Genetic diversity of Aspergillus fumigatus in indoor hospital environments

Medical Mycology
Ricardo AraujoLeonor Gusmão

Abstract

Environmental isolates of Aspergillus fumigatus are less studied than those recovered from clinical sources. In the present study, the genetic diversity among such environmental isolates was assessed, as well as their dispersion ability and the acquisition of new strains in 19 medical units of the same hospital. A. fumigatus isolates were genotyped using a single multiplex PCR-based reaction with eight microsatellite markers and an insertion/deletion polymorphism. A total of 130 unique genotypes were found among a total of 250 A. fumigatus isolates. Genotypic diversity ranged from 0.86 to 1 in samples from hospital rooms, and there was no correlation between these samples and the presence of high-efficiency particulate air filters or any other air filtration system. Four of the six most prevalent A. fumigatus strains were recovered from water samples. The occurrence of microvariation was common among environmental isolates, which affected each of the microsatellite markers. The assessment of the genetic diversity of A. fumigatus is a useful tool for illustrating the presence or absence of specific clonal populations in a clinical setting. A. fumigatus populations were highly dynamic indoors, and new populations were found in ju...Continue Reading

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Citations

Jun 8, 2012·Journal of Clinical Microbiology·Simone M T CampsPaul E Verweij
Jul 21, 2015·Environmental Microbiology Reports·Joana TeixeiraRicardo Araujo
Aug 16, 2011·The Journal of Hospital Infection·K A EtienneS A Balajee
Oct 27, 2010·Revista iberoamericana de micología·Ana AbadAitor Rementeria
May 26, 2015·Fungal Genetics and Biology : FG & B·J H C WoudenbergP W Crous
May 15, 2012·Journal of Medical Microbiology·Ann PackeuFrançoise Symoens
Apr 20, 2016·Frontiers in Microbiology·Carys A CroftScott J Tebbutt
Jul 7, 2016·Parasitology Research·Elodie MaisonneuveMarie-Hélène Rodier
May 12, 2017·Clinical Microbiology Reviews·Alexandre AlanioStéphane Bretagne
Sep 25, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sophie T LoeffertPhilippe Vanhems
Dec 23, 2020·Journal of Fungi·Josué J da SilvaMaria Helena P Fungaro
Mar 7, 2021·Journal of Fungi·Mireille H van der TorreLilyann Novak-Frazer
Jul 29, 2021·Medical Mycology·Aryse Martins MeloMelissa Orzechowski Xavier

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Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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