Genetic diversity of Echinococcus multilocularis on a local scale

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
J KnappR Piarroux

Abstract

Echinococcusmultilocularis is the causative agent of human Alveolar Echinococcosis (AE), and it is one of the most lethal zoonotic infections in the Northern Hemisphere. In France, the eastern and central regions are endemic areas; Franche-Comté, Lorraine and Auvergne are particularly contaminated. Recently, several human cases were recorded in the French Ardennes area, a region adjacent to the western border of the E. multilocularis range in France. A previous study in this focus described a prevalence of over 50% of the parasite in red foxes. The present study investigated the genetic diversity of adult worms collected from foxes in a 900km(2) area in the Ardennes. Instead of a conventional mitochondrial target (ATP6), two microsatellite targets (EmsB and NAK1) were used. A total of 140 adult worms isolated from 25 red foxes were genotyped. After hierarchical clustering analyses, the EmsB target enabled us to distinguish two main assemblages, each divided into sub-groups, yielding the differentiation of six clusters or assemblage profiles. Thirteen foxes (52% of the foxes) each harbored worms from at least two different assemblage profiles, suggesting they had become infected by several sources. Using the NAK1 target, we iden...Continue Reading

References

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Mar 20, 2003·Emerging Infectious Diseases·Petra KernUNKNOWN European Echinococcosis Registry
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Citations

Jun 11, 2009·PLoS Neglected Tropical Diseases·Jenny KnappRenaud Piarroux
May 1, 2012·Trends in Parasitology·Rebecca K DavidsonLucy J Robertson
Apr 3, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·J KnappP Deplazes
Oct 1, 2010·Veterinary Parasitology·A CasulliT Sréter
Jan 29, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·G UmhangF Boué
Nov 19, 2015·Folia Parasitologica·Severo Vazquez-PrietoFlorencio M Ubeira
Dec 29, 2017·PLoS Neglected Tropical Diseases·Mónica J PajueloUNKNOWN Cysticercosis Working Group in Peru
Dec 7, 2021·Das Gesundheitswesen·Isabelle KwiedorJulian Schmidberger

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