Genetic Diversity of Human Adenovirus in Children with Acute Gastroenteritis, Albania, 2013-2015

BioMed Research International
G La RosaM Divizia

Abstract

The objectives of the present study were to assess the occurrence of human adenoviruses (HAdVs) in paediatric patients with gastroenteritis in Albania and to characterize HAdV strains. Faecal specimens from children admitted with acute gastroenteritis to the Paediatric Hospital in Tirana were screened for HAdV, using broad-range primers targeting the hexon gene, in combination with species-specific primers targeting the fiber gene. Phylogenetic analysis was then performed to assess the genetic relationships among the different sequences and between the sequences of the samples and those of the prototype strains. Adenovirus DNA was detected in 33/142 samples (23.2%); 14 belonged to species F (13 HAdV-41 and 1 HAdV-40), 13 to species C (1 HAdV-1, 8 HAdV-2, and 4 HAdV-5), 5 to species B (HAdV-3), and 1 to species A (HAdV-12). Rotavirus coinfection was present in 9/33 (27.2%) positive samples. In the remaining 24 positive samples (12 enteric--F species; 12 nonenteric--A, B, or C species), HAdVs were detected as unique viral pathogens, suggesting that HAdV may be an important cause of diarrhoea in children requiring hospitalization. This is the first study investigating the presence of human adenoviruses (species A-G) as etiologic a...Continue Reading

References

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Oct 16, 2007·Journal of Medical Virology·Arrivi FabianaMaurizio Divizia
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Citations

Oct 27, 2015·Journal of Medical Virology·G La RosaM Divizia
Aug 31, 2017·PloS One·Silvana Augusta Rodrigues PortesEduardo de Mello Volotão
Jan 14, 2019·Journal of Medical Virology·Kafayat Olushola ArowoloSonia Mara Raboni
Jan 19, 2021·Archives of Virology·Ellen Viana de SouzaAdriana Luchs
Jul 23, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Yasmin França Viana Pires de SouzaAdriana Luchs
Jul 29, 2021·Microbiology Spectrum·Maria Antonia De FrancescoArnaldo Caruso
Nov 19, 2021·Food and Environmental Virology·Fernando Santos LimaLilian Carla Carneiro

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Methods Mentioned

BETA
PCR

Software Mentioned

MEGA
BLAST

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