Genetic diversity of Plasmodium falciparum merozoite surface protein-1 block 2 in sites of contrasting altitudes and malaria endemicities in the Mount Cameroon region.

The American Journal of Tropical Medicine and Hygiene
Samuel WanjiClaude L Charvet

Abstract

The present study analyzed the relationship between the genetic diversity of Plasmodium falciparum and parasitologic/entomologic indices in the Mount Cameroon region by using merozoite surface protein 1 as a genetic marker. Blood samples were collected from asymptomatic children from three altitude zones (high, intermediate, and low). Parasitologic and entomologic indices were determined by microscopy and landing catch mosquito collection/circumsporozoite protein-enzyme-linked immunosorbent assay, respectively. A total of 142 randomly selected P. falciparum-positive blood samples were genotyped by using a nested polymerase chain reaction-based technique. K-1 polymerase chain reaction products were also sequenced. As opposed to high altitude, the highest malaria prevalence (70.65%) and entomologic inoculation rate (2.43 infective/bites/night) were recorded at a low altitude site. Seven (18.91%), 22 (36.66%), and 19 (42.22%) samples from high, intermediate, and low altitudes, respectively, contained multiclonal infections. A new K-1 polymorphism was identified. This study shows a positive non-linear association between low/intermediate altitude (high malaria transmission) and an increase in P. falciparum merozoite surface protein...Continue Reading

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Citations

Sep 2, 2015·The Korean Journal of Parasitology·Denise Patricia Mawili-MboumbaMarielle Karine Bouyou-Akotet
Apr 18, 2014·Journal of Immunology Research·Leidiane Amorim SoaresPaulo Afonso Nogueira
Sep 30, 2016·BMC Infectious Diseases·Ayukenchengamba BatePascal O Bessong
Apr 30, 2016·PLoS Neglected Tropical Diseases·Tebit E KwentiTayong D B Kwenti
Aug 30, 2019·BMC Public Health·Aliyu MohammedEllis Owusu-Dabo

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