Genetic diversity of the C protein beta-antigen gene and its upstream regions within clonally related groups of type Ia and Ib group B streptococci

Microbiology
Noriyuki NaganoMatsuhisa Inoue

Abstract

C protein beta antigen (Bac), a surface protein of group B streptococci (GBS), is known to concurrently bind the Fc portion of IgA and factor H (FH). The authors' previous work has demonstrated that mRNA expression levels show diversity among clonally related strains containing genes (bac) encoding Bac, with high expression noted in invasive strains. In this study, the bac gene and upstream regions containing putative promoters, three ORFs and an IS1381 insertion sequence were characterized. Three invasive strains showed high bac expression levels and did not show any notable mutations except one strain producing Bac that was able to bind FH but not IgA. A deletion of 51 amino acid residues, including part of the Bac IgA-binding region, was identified and hypothesized to contribute to the loss of the IgA-binding ability of this strain. A vaginal strain that showed somewhat higher bac expression levels and produced Bac lacking immunoreactivity contained an 11 bp deletion, which generated a premature termination codon, in the region preceding the IgA-binding region. In another vaginal strain that did not express bac, disruption of the upstream ORFs of the sensor histidine kinase and DNA-binding response regulator, due to frameshi...Continue Reading

References

Nov 2, 1976·The Journal of Experimental Medicine·K Whaley, S Ruddy
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J M WeilerD T Fearon
Nov 1, 1991·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A I NaessJ A Maeland
Oct 15, 1990·The Biochemical Journal·M A Kerr
Nov 1, 1984·The Journal of Experimental Medicine·G J Russell-Jones, E C Gotschlich
Jan 1, 1994·Progress in Nucleic Acid Research and Molecular Biology·S W PeltzA Jacobson
Nov 1, 1996·Trends in Biochemical Sciences·M J Ruiz-EchevarriaS W Peltz
Apr 1, 1997·Journal of Bacteriology·A R Sánchez-BeatoJ L García
Sep 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·J Mahillon, M Chandler
Feb 19, 2000·Current Opinion in Immunology·G LindahlE Johnsson
Jan 29, 2002·The Journal of Biological Chemistry·Thomas AreschougGunnar Lindahl
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hanna JarvaSeppo Meri
Feb 5, 2002·Journal of Clinical Microbiology·Fanrong KongGwendolyn L Gilbert
May 15, 2003·Folia Microbiologica·A DmitrievY H Yang
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sandhya DaveLarry S McDaniel
Jan 18, 2005·Clinical Microbiology Reviews·Gunnar LindahlThomas Areschoug

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Citations

Sep 24, 2008·Antimicrobial Agents and Chemotherapy·Noriyuki NaganoYoshichika Arakawa
Dec 14, 2007·Journal of Clinical Microbiology·Anja SiggeBarbara Spellerberg
Feb 24, 2009·Biochemistry. Biokhimii︠a︡·T N Kazeeva, A B Shevelev
Feb 2, 2021·The EMBO Journal·Nina M van SorgeAlex J McCarthy

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