Genetic diversity, population structure and drug resistance of Mycobacterium tuberculosis in Peru

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
C A TaypeM A Shaw

Abstract

This paper presents the first evaluation of the molecular epidemiology of Mycobacterium tuberculosis in Peru. We characterised 323 isolates using spoligotyping and mycobacterial interspersed repetitive units variable number tandem repeats (MIRU-VNTR) typing. We aimed to determine the levels of genetic diversity and genetic differentiation among and within Peruvian isolates and the epidemiological factors which may be driving patterns of population structure and evolution of M. tuberculosis in Peru. Our results compared to the fourth international spoligotyping database (SpolDB4) and MIRU-VNTRplus, show that the main M. tuberculosis families present are Latin American-Mediterranean, Haarlem, T, and Beijing. Bayesian clustering recovered 15 groups in the Peruvian M. tuberculosis isolates, among which two were composed mainly of orphans, implying the presence of native "Peruvian" strains not previously reported. Variable levels of association with drug resistance were observed, with Beijing genotypes not showing any association with multidrug resistance, while in other groups MIRU-VNTR loci 2, 23, 31, and 40 were found to be associated with the multidrug-resistant tuberculosis (MDR-TB) phenotype, suggesting that a linkage disequib...Continue Reading

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Citations

Sep 6, 2008·Canadian Journal of Microbiology·G Vázquez-MarrufoM S Vázquez-Garcidueñas
Mar 24, 2016·Molecular Phylogenetics and Evolution·Igor MokrousovOlga Narvskaya
Apr 23, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Johana MonteserinAnandi Martin
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Apr 12, 2020·Scientific Reports·Daniel Garzon-ChavezJacobus H de Waard
Dec 17, 2021·Nature Communications·Arturo Torres OrtizLouis Grandjean

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