DOI: 10.1101/480400Nov 29, 2018Paper

Genetic effect of type 2 Diabetes to the progression of Neurological Diseases

BioRxiv : the Preprint Server for Biology
Md Habibur RahmanMohammad Ali Moni

Abstract

Neurological Diseases (NDs) are progressive disorder often advances with age and comorbidities of Type 2 diabetes (T2D). Epidemiological, clinical and neuropathological evidence advocate that patients with T2D are at an increased risk of getting NDs. However, it is very little known how T2D affects the risk and severity of NDs. To tackle these problems, we employed a transcriptional analysis of affected tissues using agnostic approaches to identify overlapping cellular functions. In this study, we examined gene expression microarray human datasets along with control and disease- affected individuals. Differentially expressed genes (DEG) were identified for both T2D and NDs that includes Alzheimer Disease (AD), Parkinson Disease (PD), Amyotrophic Lateral Sclerosis (ALS), Epilepsy Disease (ED), Huntington Disease (HD), Cerebral Palsy (CP) and Multiple Sclerosis Disease (MSD). We have developed genetic association and diseasome network of T2D and NDs based on the neighborhood-based benchmarking and multilayer network topology approaches. Overlapping DEG sets go through protein-protein interaction for hub protein identification and gene enrichment using pathway analysis and gene ontology methods that enhance our understanding of th...Continue Reading

Related Concepts

Alzheimer's Disease
Amyotrophic Lateral Sclerosis
Anatomy, Regional
Biological Markers
Diabetes Mellitus, Non-Insulin-Dependent
Epilepsy
Gene Expression
Genes
Huntington Disease
Multiple Sclerosis

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