DOI: 10.1101/480806Nov 30, 2018Paper

Genetic Effects of Welding Fumes on the Progression of Neurodegenerative Diseases

BioRxiv : the Preprint Server for Biology
Humayan Kabir RanaMohammad Ali Moni


Background: Welding exposes different types of fumes, gases and radiant energy that can be potentially dangerous for unsafe welder's health. Welding fumes (WFs) are a significant problem among all those exposed. WFs are a complex mixture of metallic oxides, silicates and fluorides that may result in different health effects. If a welder inhales such fumes in large quantities over a long period of time, there is a risk of various neurodegenerative disease (NDGD) developments. Methods: We developed quantitative frameworks to identify the genetic relationship of WFs and NDGDs. We analyzed Gene Expression microarray data from WFs exposed tissues and NDGDs including Parkinson's disease (PD), Alzheimer's disease (AD), Lou Gehrig's disease (LGD), Epilepsy disease (ED), Multiple Sclerosis disease (MSD) datasets. We constructed relationship networks and identified dysregulated pathways, ontological pathways and protein-protein interaction sub-network using multilayer network topology and neighborhood-based benchmarking. Results: We observed that WFs shares 18, 16, 13, 19 and 19 differentially expressed genes with PD, AD, LGD, ED and MSD respectively. Gene expression dysregulation along with relationship networks, pathways and ontologic ...Continue Reading

Related Concepts

Alzheimer's Disease
Amyotrophic Lateral Sclerosis
Anatomy, Regional
Gene Expression
Multiple Sclerosis
Nerve Degeneration
Parkinson Disease

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