Genetic engineering: possibilities and prospects for its application in industrial microbiology

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
K Murray

Abstract

A wide range of techniques is now available for the construction of hybrid DNA molecules comprising components from disparate species. Transfer of segments of DNA from other organisms, and especially eukaryotes, to Escherichia coli permits their preparation in quantities sufficient for detailed analysis of their structure and mechanism of expression. This information could be exploited to enhance the quantity or quality of polypeptide products from bacterial cells. Greatly increased yields of bacterial enzymes have been obtained in this way in several instances. The approaches that have been pioneered with bacteria are currently being applied to higher organisms. Much work is in progress with yeasts, in which transformation has been successfully demonstrated, with animal viruses and cells in culture and with some plant systems and offers the promise of wider application of genetic engineering in the not too distant future.

Citations

Feb 22, 1982·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A Spinks
Aug 31, 1989·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K MurrayP G Ashton-Rickardt
Jun 1, 1995·The Journal of Applied Bacteriology·L H AbabouchF F Busta
Jun 1, 1987·The Journal of Applied Bacteriology·L Ababouch, F F Busta

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