PMID: 8949979Oct 1, 1996Paper

Genetic epidemiology of dyslipidaemia and atherosclerosis

Annals of Medicine
M A Austin

Abstract

The clinical relevance of the heterogeneity in the size and density of low-density lipoprotein (LDL) particles is now widely recognized. The evidence from epidemiological studies, family studies and twins studies demonstrates that small, dense LDL (LDL subclass phenotype B) is a common, genetically influenced risk factor for coronary heart disease (CHD). Several atherogenic mechanisms have been proposed to explain the association of small, dense LDL with CHD, including evidence that small, dense LDL is an integral feature of the insulin resistance syndrome. Furthermore, a recent study in elderly Finnish men and women has shown that phenotype B prospectively predicts non-insulin-dependent diabetes mellitus (NIDDM). In addition, ongoing studies of large Japanese-American kindreds will provide valuable data for evaluating small, dense LDL as a marker for genetic susceptibility to both CHD and NIDDM in a high-risk ethnic group.

References

Nov 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J R McNamaraE J Schaefer
Dec 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·K R FeingoldR M Krauss
Jan 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·P M NishinaR M Krauss
Jan 1, 1994·International Journal of Clinical & Laboratory Research·M A Austin
Dec 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·K L EdwardsJ V Selby
Jul 27, 1994·JAMA : the Journal of the American Medical Association·A H Slyper
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·D L TribbleR M Krauss
Jul 1, 1993·The Journal of Clinical Investigation·G M ReavenR M Krauss

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Citations

Dec 2, 1999·Atherosclerosis·D L Rainwater
Aug 25, 2001·The British Journal of Nutrition·F BrancaH Verhagen
Jul 30, 2002·American Journal of Public Health·George Davey Smith, Carole Hart

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