Genetic epidemiology

British Medical Bulletin
P Sham

Abstract

Studies of families, twins, and adoptees have helped to quantify the genetic contributions to and overlaps between depression, anxiety, phobias and alcoholism, and to refine the boundaries of the schizophrenia spectrum. Analyses of covariance structures in twin data have confirmed genetic susceptibility and recent life stresses as the major determinants of depression. Genetic modelling of family data on schizophrenia and bipolar disorder indicates three or more common genes each having a small multiplicative effect on risk, although rare major genes may be present in some families. Linkage studies have localised genes for familial Alzheimer's disease on chromosomes 14 and 21; disease mutations on these chromosomes have since been isolated. Association studies have identified susceptibility (or protective) genes for Alzheimer's disease and alcoholism. Several tentative linkage and association findings in schizophrenia and bipolar disorder require further study.

Citations

May 2, 2001·The British Journal of Psychiatry : the Journal of Mental Science·M CannonP B Jones
Jul 27, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vanessa Aguiar-PulidoCristian R Munteanu
Nov 6, 1998·Statistical Methods in Medical Research·P C Sham
Apr 24, 2001·The British Journal of Psychiatry. Supplement·J M Neiderhiser
Sep 1, 1996·The British Journal of Psychiatry : the Journal of Mental Science·N Craddock
Jan 5, 2000·The British Journal of Psychiatry : the Journal of Mental Science·A HodgesE Johnstone
Jun 30, 2009·Biochimica Et Biophysica Acta·Tania L RothJoel E Kleinman

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