Genetic, epigenetic, and clinicopathologic features of gastric carcinomas with the CpG island methylator phenotype and an association with Epstein-Barr virus

Cancer
Masanobu KusanoTakashi Tokino

Abstract

The CpG island methylator phenotype (CIMP), which is characterized by simultaneous methylation of the CpG islands of multiple genes, has been recognized as one of the important mechanisms in gastrointestinal carcinogenesis. Methylation of the 5 methylated-in-tumors (MINT) loci and 12 tumor-related genes in 78 primary gastric carcinomas was examined using combined bisulfite-restriction analysis. Epstein-Barr virus (EBV)-associated gastric tumors were detected using real-time polymerase chain reaction analysis followed by an evaluation of the correlations between CIMP status, EBV-association, and genetic alteration of p53 and K-ras. The authors compared the clinicopathologic features of gastric carcinomas that had high CIMP methylation (CIMP-H) with tumors that had low CIMP methylation (CIMP-L) or negative CIMP methylation (CIMP-N). The methylation profiles of 12 genes showed nonrandom methylation, supporting the presence of CIMP in gastric carcinoma. No p53 mutations were detected among CIMP-H tumors, and no EBV association was detected in tumors that showed mutation of p53 and K-ras. In a multiple logistic regression model with CIMP-H as the dependent variable, proximal location (P = .011), diffuse type (P = .019), and less adv...Continue Reading

References

Jun 1, 1992·Journal of Virology·P EffertN Raab-Traub
Jan 1, 1992·Journal of Clinical Microbiology·C L ClaytonS Tabaqchali
Oct 17, 1991·The New England Journal of Medicine·J ParsonnetR K Sibley
Apr 1, 1990·Gastroenterology·D M NanusA P Albino
Aug 11, 1994·Nucleic Acids Research·S J ClarkM Frommer
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·L SzekelyK G Wiman
Mar 1, 1997·Japanese Journal of Cancer Research : Gann·H OjimaY Nagamachi
Jun 15, 1997·Nucleic Acids Research·Z Xiong, P W Laird
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·M ToyotaJ P Issa
Sep 25, 1999·International Journal of Cancer. Journal International Du Cancer·H SuzukiK Imai
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·M ToyotaJ P Issa
Jun 1, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·Y H ShimJ Y Ro
Jun 4, 2002·Nature Reviews. Genetics·Peter A Jones, Stephen B Baylin
Oct 9, 2002·The American Journal of Pathology·Bastiaan P van ReesG Johan A Offerhaus
Dec 4, 2002·Japanese Journal of Cancer Research : Gann·Toshiya OsawaMasashi Fukayama
Aug 2, 2003·Lancet·Peter Hohenberger, Stephan Gretschel
Oct 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·F A FeltusP M Vertino
Nov 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Biao HeDavid M Jablons
Mar 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hye Seung LeeWoo Ho Kim
Sep 14, 2004·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Masako UenoKohzoh Imai
Nov 3, 2004·Gastroenterology·Asif Rashid, Jean Pierre J Issa

❮ Previous
Next ❯

Citations

Dec 14, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yoshichika OishiFumio Itoh
Feb 1, 2012·Cancer Letters·Edward S GreenbergDave S B Hoon
Jul 29, 2010·Expert Reviews in Molecular Medicine·Yutaka Kondo, Jean-Pierre J Issa
Jun 7, 2013·Journal of Human Genetics·Kiyoshi AsadaToshikazu Ushijima
May 12, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Katsuhiko NoshoShuji Ogino
Dec 23, 2006·Nature Reviews. Cancer·Ciaran B J WoodmanLawrence S Young
Apr 2, 2009·Journal of Gastroenterology and Hepatology·Ju-Han LeeYoung-Sik Kim
Jun 4, 2010·Pathology International·Masashi Fukayama
Feb 19, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Atsushi TanemuraDave S B Hoon
Jan 5, 2011·Infectious Agents and Cancer·Julie L RyanMargaret L Gulley
Jun 4, 2011·Acta chirurgica Iugoslavica·Marjan Micev, Milena Cosić-Micev
Jan 25, 2013·Viruses·Hisashi IizasaHironori Yoshiyama
Nov 26, 2009·World Journal of Gastroenterology : WJG·Satoshi YamaokaYasuhisa Shinomura
Jan 22, 2011·World Journal of Gastroenterology : WJG·Stefania NobiliGabriella Nesi
Oct 11, 2012·World Journal of Gastroenterology : WJG·Ji-Bin LiuFu-Lin Qiang
Dec 14, 2012·World Journal of Gastroenterology : WJG·Yasutaka SukawaYasuhisa Shinomura
Dec 1, 2009·Epigenomics·Minoru ToyotaYasuhisa Shinomura
Jun 25, 2013·Pharmacology & Therapeutics·Marc TänzerMichael Quante
Jul 13, 2014·Biochemical and Biophysical Research Communications·Hiromu SuzukiMasahiro Kai
Mar 7, 2012·Journal of Clinical Gastroenterology·Jian-Ning ChenChun-Kui Shao
Nov 12, 2014·Cancers·Jun NishikawaIsao Sakaida
May 24, 2012·Expert Review of Molecular Diagnostics·Kelly T HuynhDave S B Hoon
Jun 19, 2012·Expert Review of Molecular Diagnostics·Tomomitsu Tahara, Tomiyasu Arisawa
Mar 16, 2016·Oxidative Medicine and Cellular Longevity·Aldo GiudiceMaurizio Montella
Jan 31, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shuichi MiyamotoNaoya Sakamoto
Nov 8, 2011·Biochimica Et Biophysica Acta·Laura A E HughesManon van Engeland
Mar 2, 2016·Nature Reviews. Clinical Oncology·Florian Lordick, Yelena Y Janjigian
Jul 8, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yujun LiPeng Hou
Apr 2, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Feryel KsiaaMounir Trimeche
May 12, 2009·Seminars in Cancer Biology·Hans Helmut NillerJanos Minarovits
Apr 2, 2010·The Journal of Investigative Dermatology·Altaf A DarMohammed Kashani-Sabet
Mar 18, 2008·Human Pathology·Andrea T Deyrup
Jul 12, 2008·Cancer Science·Masashi FukayamaHiroshi Uozaki
Nov 7, 2006·Cancer Science·Kimishige AkinoTakashi Tokino
Oct 9, 2012·Journal of Surgical Oncology·Yelena Y Janjigian, David P Kelsen

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