Abstract
Ten to twenty percent of newly diagnosed glioblastoma (GBM) patients initially present with multiple lesions, termed multifocal or multicentric GBM (M-GBM). The prognosis of these patients is poorer than that of solitary GBM (S-GBM) patients. However, it is unknown whether multifocality has a genetic, epigenetic, or molecular basis. Here, we identified the genetic and epigenetic characteristics of M-GBM by performing a comprehensive analysis of multidimensional data, including imaging, genetic, epigenetic, and gene expression profiles, from 30 M-GBM cases in The Cancer Genome Atlas database and comparing the results with those of 173 S-GBM cases. We found that M-GBMs had no IDH1, ATRX, or PDGFRA mutations and were significantly associated with the mesenchymal subtype. We also identified the CYB5R2 gene to be hypo-methylated and overexpressed in M-GBMs. The expression level of CYB5R2 was significantly associated with patient survival in two major independent GBM cohorts, totaling 758 cases. The IDH1 mutation was markedly associated with CYB5R2 promoter methylation, but the survival influence of CYB5R2 was independent of IDH1 mutation status. CYB5R2 expression was significantly associated with collagen maturation and the cataboli...Continue Reading
References
Feb 13, 2004·Bioinformatics·Laurent GautierRafael A Irizarry
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
May 15, 2007·International Journal of Radiation Oncology, Biology, Physics·Timothy N ShowalterMaria Werner-Wasik
Sep 6, 2008·Nature·UNKNOWN Cancer Genome Atlas Research Network
Nov 1, 2008·Cancer·Doo-Sik KongDo-Hyun Nam
Aug 10, 2010·Journal of Neurosurgery·Wael HassaneenRaymond Sawaya
Mar 18, 2011·Oncology·Sotirios Giannopoulos, Athanassios P Kyritsis
Mar 29, 2011·Chinese Journal of Cancer·David CogdellWei Zhang
Feb 11, 2012·AJNR. American Journal of Neuroradiology·J A CarrilloW B Pope
Jul 20, 2012·Acta Neuropathologica·Pierre BadyMonika E Hegi
Aug 14, 2012·Acta Neuropathologica·Xiao-Yang LiuNada Jabado
Aug 28, 2012·Journal of Neurosurgery·Chirag G PatilMiriam Nuño
Aug 29, 2012·Genes & Development·Masato SasakiTak Wah Mak
Jan 29, 2013·Journal of Neuro-oncology·Reena P ThomasSeema Nagpal
Apr 17, 2013·Journal of Neuro-oncology·Joshua T McKenzieJohn C Breneman
May 2, 2013·Cancer Medicine·Emil LouJames J Vredenburgh
Jul 31, 2013·Prostate Cancer and Prostatic Diseases·J M DevaneyB Kwabi-Addo
Aug 13, 2013·Oncogene·J-P PradereR F Schwabe
Oct 15, 2013·Cell·Cameron W BrennanUNKNOWN TCGA Research Network
Nov 7, 2013·JAMA : the Journal of the American Medical Association·Antonio Omuro, Lisa M DeAngelis
Dec 18, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xue XiaoXianjie Zeng
Jan 2, 2014·Case Reports in Medicine·Sophia F ShakurHamad I Farhat
Jan 5, 2014·Chinese Journal of Cancer·John G Wolbers
May 17, 2014·Neuro-oncology·Anne L BaldockKristin R Swanson
Jul 6, 2014·Journal of Neuro-oncology·Anna K PaulssonMichael D Chan
Aug 27, 2014·JAMA Neurology·Zorbey TurkalpSunit Das
Nov 28, 2014·Acta Neuropathologica·David E ReussAndreas von Deimling
Nov 28, 2014·Nucleic Acids Research·UNKNOWN Gene Ontology Consortium
Jan 22, 2015·Nucleic Acids Research·Matthew E RitchieGordon K Smyth
May 7, 2015·Acta Neuropathologica·Pieter WesselingArie Perry
May 7, 2015·Acta Neuropathologica·Kenneth AldapeAndreas von Deimling
Citations
Feb 18, 2016·Chinese Medical Journal·Qiu-Ju LiCheng-Yin Liu
May 6, 2016·Frontiers in Surgery·Amy BradshawTinte Itinteang
Jun 12, 2016·Briefings in Functional Genomics·Veronique G LeBlanc, Marco A Marra
Jan 5, 2017·PloS One·Huixia ZhuChunlin Xia
Feb 16, 2017·Neuro-oncology·Khalil Abou-El-ArdatBarbara Klink
Mar 7, 2017·Nature Genetics·Jin-Ku LeeDo-Hyun Nam
Nov 22, 2017·International Journal of Molecular Sciences·Michael C BurgerJoachim P Steinbach
Apr 19, 2018·Critical Reviews in Clinical Laboratory Sciences·Ivana Jovčevska
Nov 16, 2017·Neurosurgical Review·Davide Tiziano Di CarloPaolo Perrini
Feb 13, 2018·Neuro-oncology·UNKNOWN GLASS Consortium
Sep 12, 2019·Frontiers in Oncology·Jo-Heon KimKyung-Hwa Lee
Sep 9, 2017·Advances in Anatomic Pathology·Murat Gokden
Feb 19, 2020·FEBS Open Bio·Fuhua YangQilin Huang
May 23, 2020·Journal of Neuro-oncology·Antonio DonoYoshua Esquenazi
Aug 29, 2018·Nature Medicine·Johanna KlughammerChristoph Bock
Aug 23, 2017·Computational and Mathematical Methods in Medicine·Tabea TreppmannManuela Zucknick
Sep 29, 2018·Nature Genetics·Jin-Ku LeeDo-Hyun Nam
Nov 18, 2018·The Pharmacogenomics Journal·Casey R DorrUNKNOWN for DeKAF Genomics
Dec 29, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yao LiSheng-Qing Lv
Jan 16, 2021·Chinese Neurosurgical Journal·Zuo-Xin ZhangSheng-Qing Lv
Feb 15, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Alexandra Benouaich-AmielShlomit Yust-Katz
Jan 9, 2021·Signal Transduction and Targeted Therapy·Sijia LiuPeter Ten Dijke
Mar 5, 2021·Genomics, Proteomics & Bioinformatics·Zheng ZhaoTao Jiang
Mar 7, 2021·Cancers·Aline P BeckerArnab Chakravarti
May 1, 2021·Radiologic Clinics of North America·Sangam Kanekar, Brad E Zacharia
Jun 23, 2020·Neurocirugía·Daniele ArmocidaAntonio Santoro
Aug 20, 2021·Frontiers in Genetics·Zhuliang YangXiurong Yang
Aug 30, 2021·Radiation Oncology·Daniel Felix FleischmannMaximilian Niyazi
Sep 8, 2021·Frontiers in Oncology·Chiara MoriconiMark Gumbleton