Genetic epistasis between killer immunoglobulin-like receptors and human leukocyte antigens in Kawasaki disease susceptibility

Genes and Immunity
G BossiM Martinetti

Abstract

Kawasaki disease (KD) is a pediatric acute multisystemic vasculitis complicated by development of coronary artery lesions. The breakthrough theory on KD etiopathogenesis points to pathogens/environmental factors triggered by northeastern wind coming from China. Natural Killer cells and T lymphocytes express the inhibitory/activating Killer Immunoglobulin-like Receptors (KIR) to elicit an immune response against pathogens by binding to human leukocyte antigens (HLA) class I epitopes. We first report on the role of KIR/HLA genetic epistasis in a sample of 100 Italian KD children. We genotyped KIR, HLA-A, HLA-B and HLA-C polymorphisms, and compared KD data with those from 270 Italian healthy donors. The HLA-A*11 ligand for KIR2DS2/2DS4/3DL2 was a KD susceptibility marker by itself (odds ratio (OR)=3.85, confidence interval (CI)=1.55-9.53, P=0.004). Although no epistasis between HLA-A*11 and KIR2DS2/S4 emerged, HLA-A*11 also engages KIR3DL2, a framework gene encoding for a pathogen sensor of CpG-oligodeoxynucleotides (CpG-ODN), and KD blood mononuclear cells are actually prone to pathogen CpG-ODN activation in the acute phase. Moreover, carriers of KIR2DS2/HLA-C1 and KIR2DL2/HLA-C1 were more frequent among KD, in keeping with data ...Continue Reading

References

Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T NamekawaJ J Goronzy
Aug 11, 2004·Lancet·Jane C Burns, Mary P Glodé
Dec 3, 2004·Pediatrics·Jane W NewburgerUNKNOWN Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American H
Apr 6, 2005·The Journal of Experimental Medicine·Sumati Rajagopalan, Eric O Long
Jul 28, 2005·Clinical and Experimental Immunology·T MatsubaraS Furukawa
Mar 2, 2006·Arthritis and Rheumatism·Risa MiyashitaKatsushi Tokunaga
Mar 15, 2006·The Journal of Experimental Medicine·Makoto YawataPeter Parham
Jun 20, 2007·Circulation·Brian W McCrindleUNKNOWN Pediatric Heart Network Investigators
Feb 6, 2009·PLoS Medicine·Julian LittleUNKNOWN STrengthening the REporting of Genetic Association Studies
Aug 10, 2010·Annual Review of Medicine·Anne H Rowley
May 10, 2011·Autoimmunity Reviews·Iliana AlexoudiGeorge Vaiopoulos
Nov 15, 2011·Nature Genetics·Chiea Chuen KhorUNKNOWN Blue Mountains Eye Study
Jan 18, 2012·Pediatrics·Hiromi MutaYosikazu Nakamura
Feb 7, 2012·Journal of Epidemiology·Ritei Uehara, Ermias D Belay
Jun 27, 2012·Brain : a Journal of Neurology·Gurman KaurLars Fugger
Feb 1, 2013·Clinical and Vaccine Immunology : CVI·Stanislaw SchmidtThomas Lehrnbecher
Feb 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jingxian LiuEe Chee Ren
May 21, 2014·Proceedings of the National Academy of Sciences of the United States of America·Xavier RodóJosep-Anton Morguí

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Citations

Jan 8, 2017·Journal of Cellular and Molecular Medicine·Domenico Del PrincipeElisabetta Straface
Dec 2, 2017·European Journal of Immunology·Cristina CapittiniMiryam Martinetti
Jun 10, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Dalila MeleStefania Varchetta

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