Genetic epistasis in female suicide attempters

Progress in Neuro-psychopharmacology & Biological Psychiatry
Pablo Fernandez-NavarroEnrique Baca-García

Abstract

Complex behaviors such as suicidal behavior likely exhibit gene-gene interactions. The main aim of this study is to explore potential single nucleotide polymorphisms combinations with epistatic effect in suicidal behavior using a data mining tool (Multifactor Dimensionality Reduction). Genomic DNA from peripheral blood samples was analyzed using SNPlex Technology. Multifactor Dimensionality Reduction was used to detect epistatic interactions between single nucleotide polymorphisms from the main central nervous system (CNS) neurotransmitters (dopamine: 9; noradrenaline: 19; serotonin: 23; inhibitory neurotransmitters: 60) in 889 individuals (417 men and 472 women) aged 18 years or older (585 psychiatric controls without a history of suicide attempts, and 304 patients with a history of suicide attempts). Individual analysis of association between single nucleotide polymorphisms and suicide attempts was estimated using logistic regression models. Multifactor Dimensionality Reduction showed significant epistatic interactions involving four single nucleotide polymorphisms in female suicide attempters with a classification test accuracy of 60.7% (59.1%-62.4%, 95% CI): rs1522296, phenylalanine hydroxylase gene (PAH); rs7655090, dopami...Continue Reading

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Citations

Apr 1, 2014·Revista colombiana de psiquiatría·Paula Andrea OrtegaJorge Mauricio Cuartas
Sep 3, 2014·Molecular Psychiatry·M SokolowskiD Wasserman
May 23, 2015·Journal of the American Heart Association·Sri N BatchuVyacheslav A Korshunov
May 3, 2019·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Thelma B González-CastroJosé J Martínez-Magaña

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