Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice.

Genetics
K A GouldE S Lander

Abstract

As genetic mapping of quantitative trait loci (QTL) becomes routine, the challenge is to identify the underlying genes. This paper develops rigorous genetic tests for evaluation of candidate genes for a QTL, involving determination of allelic status in inbred strains and fine-structure genetic mapping. For the Mom1 modifier of intestinal adenomas caused by ApcMin, these tests are used to evaluate two candidate genes: Pla2g2a, a secretory phospholipase, and Rap1GAP, a GTPase activating protein. Rap1GAP passes the first test but is excluded by a single fine-structure recombinant. Pla2g2a passes both tests and is a strong candidate for Mom1. Significantly, we also find that ApcMin-induced adenomas remain heterozygous for the Mom1 region, consistent with Mom1 acting outside the tumor lineage and encoding a secreted product.

Citations

Jun 24, 2009·BMC Cancer·Paul JedlickaArthur Gutierrez-Hartmann
May 4, 2004·Trends in Cardiovascular Medicine·Sarah Jane George, Amrita Dwivedi
Sep 12, 2006·The Journal of Nutritional Biochemistry·Andrea K LawranceRima Rozen
Jul 31, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·W F DoveA R Shoemaker
Oct 16, 1999·Science·S J O'BrienJ A Marshall Graves
Oct 7, 2008·World Journal of Gastroenterology : WJG·Olga Martinez-Augustin, Fermin Sanchez de Medina
Mar 11, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M IlyasW F Bodmer
Jun 29, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Dai ShidaHirokazu Nagawa
Apr 2, 2005·Journal of Radiation Research·Mieko Okamoto, Hiromichi Yonekawa
Mar 21, 1998·Methods : a Companion to Methods in Enzymology·C H Warden, J S Fisler
May 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Andrew T ThliverisMichael A Newton
Feb 24, 2006·Nature Reviews. Cancer·Kent Hunter
Aug 17, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M IlyasW F Bodmer
Sep 6, 2005·Nature Genetics·Yeong-Gwan ParkKent W Hunter
Apr 17, 2007·Genetics·Lawrence N KwongWilliam F Dove
Apr 22, 2014·G3 : Genes - Genomes - Genetics·William F DoveThomas M Keane
May 25, 2007·Nature Reviews. Cancer·John D Potter
Apr 16, 2008·Infection and Immunity·Claude M NagamineDavid B Schauer
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·K A Gould, W F Dove
Jun 10, 2008·Pathology, Research and Practice·Amy E McCartAndrew Silver
Jun 30, 2000·Biochemical and Biophysical Research Communications·K A SteinbrecherM B Cohen
Sep 20, 1997·The Journal of Biological Chemistry·E M GarabedianJ I Gordon
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·A J MerrittW F Dove
Nov 29, 2008·Cancer Science·R J A FijnemanR T Cormier
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·A R ShoemakerW F Dove
Jul 4, 2009·Carcinogenesis·Seija I OikarinenKaren A Gould
Jul 11, 1998·Experimental Lung Research·K A Gould, W F Dove
Mar 5, 2016·Cold Spring Harbor Protocols·Karlyne M Reilly
Jun 17, 2011·Nature·Jan Paul Medema, Louis Vermeulen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
K A Gould, W F Dove
Proceedings of the National Academy of Sciences of the United States of America
Jackie W HainesA Silver
© 2022 Meta ULC. All rights reserved