PMID: 9653150Jul 8, 1998Paper

Genetic evidence for a Paleolithic human population expansion in Africa

Proceedings of the National Academy of Sciences of the United States of America
D Reich, D B Goldstein

Abstract

Human populations have undergone dramatic expansions in size, but other than the growth associated with agriculture, the dates and magnitudes of those expansions have never been resolved. Here, we introduce two new statistical tests for population expansion, which use variation at a number of unlinked genetic markers to study the demographic histories of natural populations. By analyzing genetic variation in various aboriginal populations from throughout the world, we show highly significant evidence for a major human population expansion in Africa, but no evidence of expansion outside of Africa. The inferred African expansion is estimated to have occurred between 49,000 and 640,000 years ago, certainly before the Neolithic expansions, and probably before the splitting of African and non-African populations. In showing a significant difference between African and non-African populations, our analysis supports the unique role of Africa in human evolutionary history, as has been suggested by most other genetic work. In addition, the missing signal in non-African populations may be the result of a population bottleneck associated with the emergence of these populations from Africa, as postulated in the "Out of Africa" model of mod...Continue Reading

References

Dec 1, 1975·Theoretical Population Biology·P A Moran
Mar 11, 1988·Science·C B Stringer, P Andrews
Mar 31, 1994·Nature·A M BowcockL L Cavalli-Sforza
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·S HoraiN Takahata
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·D B GoldsteinM W Feldman
Aug 1, 1993·Human Molecular Genetics·J L Weber, C Wong
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·L A Zhivotovsky, M W Feldman
Nov 1, 1996·Genetics·A MochizukiY Iwasa

❮ Previous
Next ❯

Citations

Mar 30, 1999·American Journal of Physical Anthropology·J H Relethford, L B Jorde
Oct 12, 1999·American Journal of Physical Anthropology·D A MerriwetherR E Ferrell
May 10, 2005·Journal of Human Evolution·Vinayak EswaranAlan R Rogers
Jun 20, 2000·Trends in Genetics : TIG·M PrzeworskiA Di Rienzo
Aug 30, 2001·Trends in Genetics : TIG·D E Reich, E S Lander
Jun 17, 1999·Trends in Ecology & Evolution·G Luikart, P R England
Aug 17, 2002·Current Opinion in Immunology·Edward K Wakeland, Amy E Wandstrat
Nov 16, 2002·Current Opinion in Genetics & Development·Laurent Excoffier
Feb 1, 2003·Nature Reviews. Genetics·Michael Bamshad, Stephen P Wooding
Jan 10, 2003·Molecular Biology and Evolution·Nicolas RayLaurent Excoffier
Feb 18, 2009·Molecular Biology and Evolution·James X SunDavid E Reich
Nov 26, 2002·Molecular Biology and Evolution·Sebastian E Ramos-Onsins, Julio Rozas
Nov 13, 2001·Proceedings. Biological Sciences·H A LessiosB D Kessing
Mar 5, 2002·Genome Research·Carlos A DriscollStephen J O'Brien
Oct 7, 2003·Annual Review of Genomics and Human Genetics·Sarah A Tishkoff, Brian C Verrelli
Sep 27, 2008·Genome Biology·Rachele CaglianiManuela Sironi
Apr 30, 2009·PloS One·Guillaume LéotardFinn Kjellberg
Sep 3, 2010·The American Journal of Tropical Medicine and Hygiene·Helena BrocheroManuel Ruiz-García
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M C Stiner
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·L Excoffier, S Schneider
Apr 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·M C FisherJ W Taylor
Aug 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Paola SebastianiMarco F Ramoni
Feb 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·A R Rogers
Oct 11, 2015·Molecular Ecology·Dilli P RijalInger G Alsos
Sep 28, 2007·Medical and Veterinary Entomology·N AliM J Donnelly

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.