PMID: 8941765Jun 1, 1996Paper

Genetic evidence for the relationship of Porphyromonas gingivalis cysteine protease and hemagglutinin activities

Oral Microbiology and Immunology
M Yoneda, H K Kuramitsu

Abstract

Cysteine protease and hemagglutinin activities of Porphyromonas gingivalis have been implicated as virulence factors in periodontitis. In addition, a close structural relationship between these factors has been suggested. In order to examine the molecular basis for such a relationship, we constructed an isogenic mutant, G-102, of P. gingivalis 381 deficient in Arg-gingipain cysteine protease activity. The mutant displayed not only reduced protease activity but also significantly reduced hemagglutination activity compared with the wild-type strain. Therefore, this investigation provided genetic evidence for the recently proposed structural relationship between Arg-gingipain and the hemagglutinin activity of P. gingivalis strains.

References

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Citations

Nov 10, 1998·Oral Microbiology and Immunology·H K Kuramitsu
Jan 1, 1997·Journal of Periodontal Research·H KuramitsuM I Cho
Aug 9, 2005·FEMS Microbiology Letters·Mitsunori YamadaHoward K Kuramitsu
Oct 16, 1999·Periodontology 2000·S C HoltC A Genco
Mar 16, 2001·Expert Opinion on Pharmacotherapy·S Mace, D Taylor
Dec 28, 1999·Epilepsia·M V Lambert, M M Robertson
Feb 25, 1999·The Australian and New Zealand Journal of Surgery·W H Isbister
Sep 24, 1998·Infection and Immunity·Y Park, R J Lamont
Mar 6, 1998·Infection and Immunity·M TokudaH Kuramitsu
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·R J Lamont, H F Jenkinson
Oct 1, 1996·Infection and Immunity·M TokudaH K Kuramitsu

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