Genetic evidence supports secondary metabolic diversity in Prochloron spp., the cyanobacterial symbiont of a tropical ascidian

Journal of Natural Products
Eric W SchmidtMargo G Haygood

Abstract

Didemnid family ascidians commonly harbor obligate cyanobacterial symbionts, Prochloron spp., which have been proposed to biosynthesize cyclic peptides. Here, it is shown that Prochloron spp. do indeed contain genes for nonribosomal peptide biosynthesis, although genes for cyclic peptide biosynthesis have not yet been characterized. A peptide synthetase-containing open reading frame of unknown function was cloned from the Prochloron symbionts of some didemnid ascidians, but not from others. These data indicate that Prochloron spp. have variable secondary metabolic potential.

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Citations

Jun 21, 2012·The Journal of Organic Chemistry·Justyna SikorskaKerry L McPhail
Jan 12, 2012·Journal of Natural Products·Eric W SchmidtJacques Ravel
Jun 27, 2009·Journal of Natural Products·Brian T MurphyDavid G I Kingston
Jun 3, 2006·Natural Product Reports·Zhong Jin
Jul 29, 2006·Natural Product Reports·Bradley S Moore
Oct 22, 2009·Natural Product Reports·Sean F BradyEric W Schmidt
Mar 30, 2011·PloS One·Mohamed S DoniaEric W Schmidt
May 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Eric W SchmidtJacques Ravel
Nov 7, 2006·Nature Chemical Biology·Mohamed S DoniaEric W Schmidt
Nov 1, 2007·Expert Opinion on Drug Discovery·John J BowlingMark T Hamann
Mar 13, 2012·Drug Discovery Today·Edwin L Cooper, David Yao
Jun 16, 2006·FEMS Microbiology Reviews·Martin Welker, Hans von Döhren
Jan 24, 2015·Nature Reviews. Drug Discovery·Alan L HarveyRonald J Quinn
Jun 9, 2016·Natural Product Reports·Nadine ZiemertTilmann Weber
Feb 15, 2018·Natural Product Reports·Maho Morita, Eric W Schmidt
Jul 1, 2005·Chembiochem : a European Journal of Chemical Biology·Paul F LongMarcel Jaspars
Oct 3, 2018·Marine Drugs·Lei ChenGuang-Yu Wang
Feb 1, 2008·Chembiochem : a European Journal of Chemical Biology·Ryuichi SakaiHisao Kamiya
Dec 6, 2008·Chembiochem : a European Journal of Chemical Biology·Elizabeth M Nolan, Christopher T Walsh
Oct 22, 2009·Natural Product Reports·John A KalaitzisBrett A Neilan
Jul 16, 2010·Chembiochem : a European Journal of Chemical Biology·Wael E Houssen, Marcel Jaspars
Feb 26, 2009·Natural Product Reports·Jörn Piel
Dec 21, 2010·Natural Product Reports·Amy L Lane, Bradley S Moore
Jul 30, 2014·Chemical Communications : Chem Comm·Marcel Jaspars

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