Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants

International Journal of Dentistry
Maélson Klever da SilvaDaniel Fernando Pereira Vasconcelos

Abstract

Purpose. This work aimed to synthesize the results of recent meta-analysis focusing on polymorphism in inflammatory mediators and its relation with the risk of periodontitis development. Materials and Methods. A systematic search was conducted using databases for publications prior to October 2016. Three examiners extracted data from articles with a clear association between polymorphisms in the inflammatory mediator gene and the development of periodontitis through meta-analysis using the fixed or randomized statistical models to calculate the Odds Ratio with values of P < 0.05 considered significant. Results. A total of 13 meta-analysis articles with 25 polymorphisms in seven interleukins (IL-1A, IL-1B, IL-4, IL-6, IL-8, IL-10, and IL-18), three cellular receptors (Fcγ receptors: FCGR2A, FCGR3A, and FCGR3B), and five inflammatory mediators (COX-2, MMP-2, MMP-3, MMP-8, and MMP-9), with a total of 71,531 participants, approaching different classifications of the disease. Conclusion. The study demonstrated that polymorphisms in the IL-1A, IL-1B, IL-6, IL-10, MMP-3 (chronic form), and MMP-9 (chronic form) polymorphisms were significantly associated with the risk of developing periodontitis, whereas other polymorphisms in the IL-4...Continue Reading

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Citations

Oct 5, 2018·Journal of Periodontal Research·Luisa ZupinAntonietta Robino
Apr 2, 2020·Oncology Reviews·Soussan IraniMohammadreza Badiei
Jun 3, 2020·International Journal of Molecular Sciences·Syed Saad B QasimMuhammad Sohail Zafar
Jul 8, 2020·International Journal of Molecular Sciences·Petra Borilova LinhartovaLydie Izakovicova Holla
Aug 4, 2020·Journal of Leukocyte Biology·Ying ZhengWai Keung Leung
May 28, 2019·Journal of Clinical Medicine·Mélanie Rinaudo-GaujousHubert Marotte
Feb 23, 2020·BMC Oral Health·Felipe Rodolfo Pereira da SilvaJosé Fernando Marques Barcellos
Sep 11, 2018·Periodontology 2000·Kenneth S Kornman
May 9, 2019·Mediators of Inflammation·Patrícia Yumeko TsunetoAna Maria Sell
Aug 7, 2019·Journal of Clinical Periodontology·Anna-Barbara MoscickiUNKNOWN Pediatric HIV/AIDS Cohort Study
Jul 28, 2020·British Dental Journal·D Jayawardena
Nov 24, 2020·Periodontology 2000·Luciana Macchion ShaddoxLuigi Nibali
Mar 6, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Fatemeh MashhadiabbasKarim Daliri
May 27, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Valentina TaleviJean-Luc C Mougeot
Mar 31, 2021·Photodiagnosis and Photodynamic Therapy·Eduardo Quintão Manhanini SouzaLetícia Helena Theodoro
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Dec 16, 2021·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Albertas KriauciunasRasa Liutkeviciene

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