Genetic Factors in Systemic Lupus Erythematosus: Contribution to Disease Phenotype

Journal of Immunology Research
Fulvia CeccarelliFabrizio Conti

Abstract

Genetic factors exert an important role in determining Systemic Lupus Erythematosus (SLE) susceptibility, interplaying with environmental factors. Several genetic studies in various SLE populations have identified numerous susceptibility loci. From a clinical point of view, SLE is characterized by a great heterogeneity in terms of clinical and laboratory manifestations. As widely demonstrated, specific laboratory features are associated with clinical disease subset, with different severity degree. Similarly, in the last years, an association between specific phenotypes and genetic variants has been identified, allowing the possibility to elucidate different mechanisms and pathways accountable for disease manifestations. However, except for Lupus Nephritis (LN), no studies have been designed to identify the genetic variants associated with the development of different phenotypes. In this review, we will report data currently known about this specific association.

References

Mar 1, 1996·The Journal of Experimental Medicine·E Stüber, W Strober
Mar 13, 2003·Kidney International·Fotini B KarassaUNKNOWN Fc gamma RIIIA-SLE meta-analysis investigators
Oct 17, 2003·The New England Journal of Medicine·Melissa R ArbuckleJohn B Harley
Oct 27, 2004·Seminars in Arthritis and Rheumatism·Yaniv ShererYehuda Shoenfeld
Oct 6, 2006·Springer Seminars in Immunopathology·John B HarleyKenneth M Kaufman
Nov 2, 2006·PLoS Medicine·Graciela S AlarcónUNKNOWN PROFILE Study Group
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ilaria PelusoGiovanni Monteleone
Sep 7, 2007·The New England Journal of Medicine·Elaine F RemmersPeter K Gregersen
Jan 22, 2008·Nature Genetics·UNKNOWN International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN)Jennifer A Kelly
Apr 29, 2008·Trends in Immunology·Giovanni MonteleoneThomas T MacDonald
Jun 17, 2008·Current Opinion in Immunology·Rosanne Spolski, Warren J Leonard
Dec 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·José C CrispínGeorge C Tsokos
Sep 18, 2009·Annals of the New York Academy of Sciences·Carlos VasconcelosBerta Martins
Sep 18, 2009·Experimental Dermatology·Diona L DamianRebecca S Mason
Oct 31, 2009·Annals of the Rheumatic Diseases·B de VriesM D Ferrari
Dec 1, 2009·Gastroenterology·Tom H KarlsenStefan Schreiber
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Abdul HakkimArturo Zychlinsky
May 25, 2010·European Journal of Internal Medicine·C TanasescuA Georgescu
Oct 19, 2010·Nature Genetics·UNKNOWN Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2Richard C Trembath
Nov 10, 2010·Nature Reviews. Rheumatology·Yun Deng, Betty P Tsao
Jan 20, 2011·Annals of Saudi Medicine·Mohamed N FarresNermine M Abd Raboh
Jan 20, 2011·Immunogenetics·Laura Espino-PaisanJose Luis Santiago
Jan 29, 2011·Genes and Immunity·B NamjouJ P Atkinson

❮ Previous
Next ❯

Citations

Sep 10, 2016·Immunological Investigations·Ouahiba BhallilMalika Essakalli
Oct 7, 2017·Current Rheumatology Reports·Yun Deng, Betty P Tsao
Jul 9, 2016·Current Opinion in Pediatrics·Aimee O HershSampath Prahalad
Jan 20, 2019·Nature Reviews. Rheumatology·Noa SchwartzChaim Putterman
May 22, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stuart J PerperStephen H Clarke
Dec 2, 2017·Clinical Genetics·S TavakolpourM Ghasemiadl
Jul 19, 2019·Scientific Reports·Meifeng XuShengxiang Xiao
Feb 3, 2020·Clinical Rheumatology·Norma Alicia Salgado-GaliciaJulio Granados
Aug 7, 2020·Expert Opinion on Investigational Drugs·Milena TocutGisele Zandman-Goddard
Jun 15, 2018·Arthritis Research & Therapy·Fulvia CeccarelliCristiano Alessandri
Nov 14, 2019·International Journal of Molecular Sciences·Fulvia CeccarelliFabrizio Conti
Aug 30, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yumi NakayamaGarth E Ringheim
Feb 25, 2021·Seizure : the Journal of the British Epilepsy Association·Adrian Rodriguez-HernandezMaria G Zavala-Cerna
Jul 13, 2021·Frontiers in Immunology·Yuyue Zuo, Guo-Min Deng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.