Abstract
Aggregation of breast cancer in families is an established risk factor associated with increased incidence of the disease, which is a leading cause of morbidity and mortality among women in this country. Three genes have now been identified that confer increased susceptibility in families with a clear hereditary (i.e., Mendelian) pattern of expression: BRCA1, BRCA2 and p53. However, a significant number of women have an identified family history of breast cancer without clear Mendelian patterns of disease. Such patterns are consistent with the effect of more common genes with lower associated risk. Some evidence is available to implicate three additional genes that fit this category: AT, ESR and HRAS1. An area of active interest is genetically mediated variation in the metabolism of estrogens, a process controlled by several genes, each with more modest effects. The interaction of genes and environmental factors in breast cancer pathogenesis is of considerable public health importance.
References
Dec 14, 1991·Lancet·M F Santibáñez-KorefM Harris
Dec 10, 1990·Science·D MalkinM A Tainsky
Oct 1, 1990·Cell Regulation·N T TelangR Narayanan
Jan 1, 1990·Genomics·J M HallM C King
May 13, 1988·Science·R M Evans
Mar 1, 1987·Human Genetics·P J McKinnon
Dec 31, 1985·Biochemistry·S C Yu, J Fishman
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J SchneiderJ Fishman
Oct 7, 1994·Science·Y MikiW Ding
Oct 1, 1995·British Journal of Cancer·D Ford, D F Easton
Jun 23, 1995·Science·K SavitskyY Shiloh
Dec 1, 1994·International Journal of Radiation Biology·D F Easton
Mar 15, 1995·Journal of the National Cancer Institute·N RoodiF F Parl
Mar 19, 1994·Lancet·D FordD E Goldgar
Dec 1, 1993·Journal of the National Cancer Institute·M P OsborneN T Telang
Aug 19, 1993·The New England Journal of Medicine·T G KrontirisN Risch
Feb 1, 1993·Pharmacology & Therapeutics·C P Martucci, J Fishman
Aug 1, 1993·Human Genetics·R WoosterM R Stratton
Jan 1, 1993·Epidemiologic Reviews·L Bernstein, R K Ross
Dec 21, 1995·Nature·R WoosterG Micklem
Jan 18, 1996·The New England Journal of Medicine·A A LangstonE A Ostrander
Jan 18, 1996·The New England Journal of Medicine·M G FitzGeraldD A Haber
Citations
Oct 18, 2000·Journal of the American Academy of Nurse Practitioners·S Cain
Jul 1, 2010·Oncology Letters·Gloria M CalafFrancisco Rothhammer
Sep 10, 2014·Oncology Letters·Shanyu GuoShougui Liu
Mar 21, 1998·Clinical Obstetrics and Gynecology·M Akashi, H P Koeffler
Aug 13, 2003·International Journal of Epidemiology·Takaaki KondoTakesumi Yoshimura
Apr 28, 2006·International Journal of Cancer. Journal International Du Cancer·Grethe AlbrektsenGunnar Kvåle
Mar 8, 2018·International Journal of Molecular Medicine·Xiao ZhengShanyu Guo
Jul 8, 2000·Annual Review of Public Health·C L RockR E Patterson
Dec 1, 2002·Nutrition Research Reviews·Julie A Lovegrove
Feb 28, 2018·Cancer Cell International·Rezvan EsmaeiliKeivan Majidzadeh-A
Oct 1, 2013·Cell·David R BlairAndrey Rzhetsky