Abstract
One of the greatest advances in Parkinson's disease (PD) research in the past two decades has been a better understanding of PD genetics. Of the many candidate genes investigated, the best studied include LRRK2, SNCA, VPS35, Parkin, PINK1, and DJ1. The authors review the key clinical features of these monogenic forms, as well as for the prevalent risk factor gene, GBA, including the phenotype, clinical course, and treatment response. They also outline areas for future investigation: longitudinal studies of PD's clinical course, the identification of its premotor manifestations, and its specific mechanisms of pathogenicity.
Citations
Jun 27, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chiara FecchioPatrizia Polverino de Laureto
Feb 6, 2019·Brain Sciences·Emilia M GattoMartin Cesarini
May 12, 2019·International Journal of Molecular Sciences·Carla Ribeiro Alvares BatistaAntonio Carlos Pinheiro de Oliveira
Nov 16, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Giovanni BellomoLucilla Parnetti
Feb 9, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Anwesha SanyalMatthew J LaVoie
Feb 15, 2020·ELife·Chi G WeindelRobert O Watson
Jun 15, 2018·International Journal of Molecular Medicine·Yunlu JiangBo Bai
Sep 12, 2019·NPJ Parkinson's Disease·Johanne LigaardLasse Pihlstrøm
Sep 12, 2018·BMC Biology·Mei ZhuClarissa L Waites
Dec 13, 2019·Journal of Neural Transmission·András SalamonLászló Vécsei
Jan 31, 2020·Frontiers in Neurology·Alessandro GialluisiTeresa Esposito
Nov 5, 2019·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Roy N AlcalayMartha Nance
Dec 24, 2019·Journal of Parkinson's Disease·Ziv Gan-OrEdward A Fon
Mar 25, 2020·International Journal of Molecular Sciences·Wioletta Rozpędek-KamińskaIreneusz Majsterek
Nov 24, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Bingying DuLijun Hou
Dec 16, 2020·Journal of Genetic Counseling·Jennifer VerbruggeTatiana Foroud
Jul 19, 2020·La Revue de médecine interne·M AubignatP Krystkowiak
Nov 22, 2020·Neurology International·Amber EdinoffIvan Urits
Oct 27, 2020·Frontiers in Aging Neuroscience·Paulina Troncoso-EscuderoRene L Vidal
Feb 23, 2021·Frontiers in Neuroscience·Yanyan ZhangTian Tian
Mar 10, 2021·Current Neurology and Neuroscience Reports·Lola CookRoy N Alcalay
Mar 12, 2021·Neuroscience Letters·Shaik Mohammad NaushadVijay Kumar Kutala
Mar 18, 2021·Scientific Reports·Martin WeberBaris Bingol
Oct 5, 2019·The Medical Clinics of North America·Katelyn PayneJoanne Wojcieszek
Apr 22, 2021·ACS Chemical Neuroscience·Xingjun MengShaogang Qu
May 1, 2021·Stem Cell Research & Therapy·Elena Coccia, Tim Ahfeldt
Jun 5, 2021·Neurobiology of Aging·Anna HofmannUNKNOWN TREND Study Consortium
Jun 11, 2021·Frontiers in Neuroscience·Lorenzo GaetaniMassimiliano Di Filippo
Jun 10, 2021·Medicinal Research Reviews·Ramón CacabelosJuan C Carril
Jul 18, 2021·NPJ Parkinson's Disease·Daniel Macías-GarcíaPablo Mir
Aug 17, 2021·Cell Calcium·Dmitry LimAlexei Verkhratsky
Aug 15, 2021·Neurobiology of Disease·Abby L Olsen, Mel B Feany
May 11, 2021·Neurology. Clinical Practice·Lola CookTatiana Foroud