Genetic gateways to COVID-19 infection: Implications for risk, severity, and outcomes

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Monojit DebnathMichael Berk

Abstract

The dynamics, such as transmission, spatial epidemiology, and clinical course of Coronavirus Disease-2019 (COVID-19) have emerged as the most intriguing features and remain incompletely understood. The genetic landscape of an individual in particular, and a population in general seems to play a pivotal role in shaping the above COVID-19 dynamics. Considering the implications of host genes in the entry and replication of SARS-CoV-2 and in mounting the host immune response, it appears that multiple genes might be crucially involved in the above processes. Herein, we propose three potentially important genetic gateways to COVID-19 infection; these could explain at least in part the discrepancies of its spread, severity, and mortality. The variations within Angiotensin-converting enzyme 2 (ACE2) gene might constitute the first genetic gateway, influencing the spatial transmission dynamics of COVID-19. The Human Leukocyte Antigen locus, a master regulator of immunity against infection seems to be crucial in influencing susceptibility and severity of COVID-19 and can be the second genetic gateway. The genes regulating Toll-like receptor and complement pathways and subsequently cytokine storm induced exaggerated inflammatory pathways ...Continue Reading

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Citations

Aug 18, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thoru Pederson
Oct 27, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ferric C FangRobert T Schooley
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