Genetic GIScience: Toward a Place-Based Synthesis of the Genome, Exposome, and Behavome

Annals of the Association of American Geographers
Geoffrey M JacquezChen Shi

Abstract

The exposome, defined as the totality of an individual's exposures over the life course, is a seminal concept in the environmental health sciences. Although inherently geographic, the exposome as yet is unfamiliar to many geographers. This article proposes a place-based synthesis, genetic geographic information science (Genetic GISc) that is founded on the exposome, genome+ and behavome. It provides an improved understanding of human health in relation to biology (the genome+), environmental exposures (the exposome), and their social, societal and behavioral determinants (the behavome). Genetic GISc poses three key needs: First, a mathematical foundation for emergent theory; Second, process-based models that bridge biological and geographic scales; Third, biologically plausible estimates of space-time disease lags. Compartmental models are a possible solution; this article develops two models using pancreatic cancer as an exemplar. The first models carcinogenesis based on the cascade of mutations and cellular changes that lead to metastatic cancer. The second models cancer stages by diagnostic criteria. These provide empirical estimates of the distribution of latencies in cellular states and disease stages, and maps of the burd...Continue Reading

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Oct 19, 2016·Journal of Dermatological Science·Jean KrutmannThierry Passeron
Apr 20, 2017·International Journal of Environmental Research and Public Health·Miranda LohJohn W Cherrie
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Oct 11, 2017·Du Bois Review : Social Science Research on Race·Nicole Kravitz-WirtzVictoria Sass
Mar 12, 2021·Brain : a Journal of Neurology·Clive E SabelBruce V Taylor

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