Genetic heterogeneity and recombination in type-3 human astroviruses

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
M C MediciA Calderaro

Abstract

Human astroviruses (HAstVs) are important enteric pathogens and can be classified genetically and antigenically into eight types. During molecular surveillance for HAstVs in Italy, sequence analysis of the diagnostic region C (about 400 nucleotide in length), located on the capsid (ORF2) gene, identified a novel type-3 strain. Upon sequencing of the full-length ORF2, the type-3 HAstV strain was characterized as a novel ORF2 genetic lineage, designated as 3c. By converse, in the ORF1b the virus was more similar to type-1 HAstVs, rather than to type-3 strains, suggesting a recombination nature, with the crossover site being mapped to the ORF1b/ORF2 junction region. Region C sequences of similar type-3 HAstV identified from European and extra-European countries were retrieved in the databases, suggesting the global distribution of this novel type-3 lineage.

References

Nov 17, 1978·Medical Microbiology and Immunology·J Kurtz, T Lee
Jun 26, 2001·Journal of Medical Virology·Q H WangH Ushijima
Jan 5, 2002·Journal of Clinical Microbiology·Susana GuixRosa M Pintó
Jan 13, 2004·Journal of Clinical Microbiology·Martha Méndez-TossCarlos F Arias
Jul 19, 2005·Emerging Infectious Diseases·Rowena A BullPeter A White
Feb 21, 2006·Emerging Infectious Diseases·Qiu-Hong WangLinda J Saif
Nov 21, 2007·The Journal of General Virology·Rowena A BullPeter A White
Jun 14, 2008·Journal of Virology·D K W ChuJ S M Peiris
Aug 28, 2010·Bioinformatics·Darren P MartinPierre Lefeuvre
Nov 26, 2010·Journal of Clinical Microbiology·Marianne WolfaardtMaureen B Taylor
Mar 5, 2011·Epidemiology and Infection·S K DeyH Ushijima
Jul 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jinhui DongYizhi Tao
Dec 17, 2011·Emerging Infectious Diseases·Salwa F AhmedDavid Wang
Feb 14, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Igor V BabkinNina V Tikunova
Aug 28, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Madhusudhan PativadaTriveni Krishnan
Aug 31, 2012·Journal of Clinical Microbiology·S De GraziaV Martella
Oct 3, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Vito MartellaSimona De Grazia
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Jan 28, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Igor V BabkinNina V Tikunova
Oct 4, 2014·Clinical Microbiology Reviews·Albert BoschSusana Guix

❮ Previous
Next ❯

Citations

Jan 27, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Hyun-Ju HaSoon-Yong Paik
Jan 23, 2016·BMC Public Health·Abir MonastiriJordi Serra-Cobo
Jul 19, 2017·Annual Review of Virology·Valerie CortezStacey Schultz-Cherry
Dec 18, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Makoto NagaiNaoaki Misawa
Nov 19, 2020·The Journal of General Virology·Chia-Ming SuCho-Hua Wan
Apr 28, 2021·Transboundary and Emerging Diseases·Floriana BonuraSimona De Grazia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.