Genetic heterogeneity within electrophoretic "alleles" of xanthine dehydrogenase in Drosophila pseudoobscura.

Genetics
R S SinghA A Felton

Abstract

An experimental plan for an exhaustive determination of genic variation at structural gene loci is presented. In the initial steps of this program, 146 isochromosomal lines from 12 geographic populations of D. pseudoobscura were examined for allelic variation of xanthine dehydrogenase by the serial use of 4 different electrophoretic conditions and a head stability test. The 5 criteria revealed a total of 37 allelic classes out of the 146 genomes examined where only 6 had been previously revealed by the usual method of gel electrophoresis. This immense increase in genic variation also showed previously unsuspected population differences between the main part of the species distribution and the isolated population of Bogotá population. The average heterozygosity at the Xdh locus is at least 72% in natural populations. This result, together with the very large number of alleles segregating and the pattern of allelic frequencies, has implications for theories of genetic polymorphism which are discussed.

Citations

Jan 1, 1978·Oecologia·Charles E Taylor, Jeffrey R Powell
Feb 1, 1978·Theoretical Population Biology·E Nevo
Dec 1, 1979·Evolution; International Journal of Organic Evolution·Richard G Harrison
Jun 1, 1979·Evolution; International Journal of Organic Evolution·Kendall W CorbinAndrew Ferguson
Oct 24, 1979·Biochimica Et Biophysica Acta·L Lock, C A Barnett
Sep 1, 1982·Evolution; International Journal of Organic Evolution·Charles F Aquadro, John C Avise
May 1, 1977·Cell·A ChovnickM McCarron
Dec 1, 1978·Evolution; International Journal of Organic Evolution·Walter F Eanes, Richard K Koehn
Sep 8, 1977·Nature·S AlahiotisE Berger
Jun 21, 1979·Journal of Theoretical Biology·M W Ho, P T Saunders
Oct 21, 1985·Journal of Theoretical Biology·D de Vienne, F Rodolphe
Jun 1, 1980·Biochemical Genetics·R A Morton, R S Singh
Jun 1, 1977·Theoretical Population Biology·J F Kingman
Mar 1, 1980·Journal of Molecular Evolution·N Takahata
Aug 1, 1980·Biochemical Genetics·T H Day, P A Buckley
Jan 1, 1981·Annals of the New York Academy of Sciences·J C King
May 1, 1986·Applied and Environmental Microbiology·R K SelanderT S Whittam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.