PMID: 9442489Jan 1, 1997Paper

Genetic homogeneity among methicillin-resistant Staphylococcus aureus strains from Saudi Arabia

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
Alex van BelkumM N al-Ahdal

Abstract

Ninety-four strains of methicillin-resistant Staphylococcus aureus (MRSA) were collected from patients nursed in several hospitals in Saudi Arabia, before they were referred to King Faisal Specialist Hospital and Research Centre for tertiary care. The hospitals were from geographically diverse regions and as such the entirety of Saudi Arabia was covered. All strains were genetically typed by random amplification of polymorphic DNA (RAPD) analysis using three different primers and a representative subset of the strains was analyzed with pulsed-field gel electrophoresis (PFGE) as well. It was concluded that 87 out of 94 (93%) belong to a single clonally related lineage of MRSA. In the other 7 cases, the DNA banding patterns were shown to differ only slightly from those determined for the clonal type. PFGE analysis confirmed the homogeneity of the collection of strains. When the RAPD and PFGE fingerprints obtained for the Saudi clone were compared to those generated for a collection of MRSA with a more diverse geographical background, it was shown that the clonal type from Saudi Arabia was not identical to any of these MRSA strains. Our data provide another example of the capacity of certain MRSA clones to expand through entire na...Continue Reading

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Citations

Dec 5, 2006·Annals of Clinical Microbiology and Antimicrobials·Manal M BaddourAmal J Fatani
Jul 5, 2012·Journal of Chemotherapy·Saber YezliZiad A Memish
Feb 15, 2003·The Journal of Hospital Infection·M V da Silva CoimbraR P Wenzel
Jan 6, 2001·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·A van Belkum
Feb 13, 1999·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·A CorsoH de Lencastre
Jun 23, 2020·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Ahmed AlbarragAmani Al-Amodi

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