Genetic hypotheses and environmental factors in the light of psychiatric morbidity in the families of schizophrenics.

The British Journal of Psychiatry : the Journal of Mental Science
D W KayR F Garside

Abstract

The hypothesis that schizophrenia and some non-psychotic abnormalities occurring in the close relatives are both manifestations of a unitary "schizoid state' due to a major dominant gene is further examined. Comparisons are made (1) of the observed and expected frequencies of the different types of parent mating; and (2) of the observed and expected risks among sibs in families with neither, or with one or both, of the parents abnormal. It is concluded that the results do not fit well with the model of inheritance of the schizoid state through a major dominant gene. Since some hereditary contribution in schizophrenia can be regarded as established, the excess of personality disorders and heavy drinking in the families is thought to be due to a combination of polygenic inheritance and environmental influences. The findings are regarded only as tentative, but suggest several hypotheses which could be tested.

References

Aug 1, 1975·The British Journal of Psychiatry : the Journal of Mental Science·D A StephensR F Garside
Jan 1, 1968·The British Journal of Psychiatry : the Journal of Mental Science·M B Hans, T H Gilmore
Mar 1, 1970·The British Journal of Psychiatry : the Journal of Mental Science·K DewhurstA L McKnight
May 1, 1969·The British Journal of Psychiatry : the Journal of Mental Science·K Abe
Aug 1, 1966·The British Journal of Psychiatry : the Journal of Mental Science·L L Heston

❮ Previous
Next ❯

Citations

Jan 1, 1980·The Psychiatric Quarterly·E Kahn
Aug 1, 1981·Psychological Medicine·D F Roberts, H G Kinnell
Jul 1, 1980·Comprehensive Psychiatry·J Rimmer, B Jacobsen
Nov 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·J ChickS Wolff
Oct 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R R LewineJ H Fryer
Aug 1, 1975·The British Journal of Psychiatry : the Journal of Mental Science·D A StephensR F Garside
Dec 1, 1982·Clinical Genetics·S S PapihaL McLeish
Aug 5, 1998·Medical Hypotheses·D F Horrobin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

The British Journal of Psychiatry : the Journal of Mental Science
D A StephensR F Garside
The British Journal of Psychiatry : the Journal of Mental Science
P RinierisC Stefanis
© 2022 Meta ULC. All rights reserved