PMID: 108520Mar 20, 1979

Genetic identification of dominant overproducing mutations: the Beadex gene

Molecular & General Genetics : MGG
E Lifschytz, M M GREEN

Abstract

A model system for the identification of presumptive overproducing mutations from among visible dominant mutations in D. melanogaster is described. An overproducing mutation is expected if a dominant mutation is readily reverted by gene deletion and if gene deletions suppress the expression of the original dominant mutation in flies heterozygous for the deletion. The Beadex (1:59.4) mutations are shown to satisfy these requirements, since a Bx dominant mutations is reverted by induced deletion [Df(Bx)/+) is wild type], and is also suppressed in trans by such a deletion [(Bx/Df)Bx) is wild type]. In addition, all 13 mutations recovered as Bx reversions or suppressors were associated with recessive held up (hdp) mutations allelic inter se, but not allelic to any known hdp gene. One such hdp mutations does not function as an independent dominant suppressor of Bx, is not always associated with Bx deletion, and in the latter situation is readily separable from Bx. We suggest that it functions as a Bx deletion, and may therefore represent the structural gene which is cis-regulated by the overproducing Bx mutations.

References

Dec 1, 1977·Cell·S Artavanis-TsakonasW J Gehring
Jan 1, 1973·The Symposium·Y Hotta, S Benzer
Jan 1, 1974·Cold Spring Harbor Symposia on Quantitative Biology·F H Schachat, D S Hogness
Dec 1, 1973·The Quarterly Review of Biology·E H Davidson, R J Britten
Jan 1, 1974·Annual Review of Genetics·J R Fincham, G R Sastry
Aug 1, 1969·Genetical Research·E Lifschytz, R Falk
Jan 1, 1953·Zeitschrift für induktive Abstammungs- und Vererbungslehre·M M GREEN
Jan 1, 1951·Cold Spring Harbor Symposia on Quantitative Biology·B McCLINTOCK

Citations

Jan 1, 1981·Molecular & General Genetics : MGG·S Kerridge
Dec 29, 1998·Trends in Genetics : TIG·I B Dawid
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·C ZengYuh Nung Jan
Mar 10, 2010·Seminars in Cell & Developmental Biology·Peter Smibert, Eric C Lai
Dec 1, 2009·Developmental Biology·Fernando BejaranoEric C Lai

Related Concepts

Genome Mapping
Drosophila melanogaster
Cistron
Genes, Dominant
Genes, Regulator
Suppressor Mutation

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