Genetic imbalances in preleukemic thymuses

Biochemical and Biophysical Research Communications
M VerlaetM P Defresne

Abstract

To understand the molecular mechanisms involved in preleukemia, the suppression subtractive hybridization method was used in a murine radiation-induced thymic lymphoma model. Seventeen mRNAs overexpressed in preleukemic thymuses were identified: mouse laminin binding protein (p40/37LBP), E25 protein, Rattus norvegicus clone BB.1.4.1, profilin, poly(A) binding protein (PABP), mouse high mobility group protein 1, topoisomerase I, clusterin, proteasome RC1 subunit, rat prostatein C3 and C1 subunits; two ESTs and four unknown genes. The overexpression of PABP, clusterin, profilin, and the p40/37LBP mRNAs was confirmed in preleukemic thymuses and can be related to some cellular events observed during the preleukemic period, i.e., alterations of cell cycle and apoptosis properties. The p40/37LBP and 67-kDa laminin receptor proteins were upregulated during the preleukemic period. The data suggest that additional studies on p40/37LBP and 67-kDa laminin receptor regulation are required to evaluate their potential role in the lymphoma prevention by TNF-alpha and IFN-gamma.

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Citations

Mar 30, 2007·Molecular Biology of the Cell·Ute NonhoffSylvia Krobitsch
Jun 28, 2006·Molecular Biology of the Cell·Anne-Sophie NicotJocelyn Laporte
Jun 20, 2006·The Journal of Biological Chemistry·Eva DizinNicole Dalla Venezia
May 6, 2003·The Journal of Nutrition·Robert J CousinsJeffrey A Bobo
Jun 28, 2002·Free Radical Biology & Medicine·Myriam VerlaetMarie-Paule Defresne

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