PMID: 11932202Apr 5, 2002Paper

Genetic immunization of neonates

Microbes and Infection
A Bot, C Bona

Abstract

The vaccination of neonates is generally difficult due to immaturity of the immune system, higher susceptibility to tolerance and potential negative interference of maternal antibodies. Studies carried out in rodents and non-human primates showed that plasmid vaccines expressing microbial antigens, rather than inducing tolerance, triggered significant humoral and cellular immunity with a Th1 component. The ability of bacterial CpG motifs to activate immature antigen-presenting cells is critical for the neonatal immunogenicity of DNA vaccines. In addition, the endogenous production of antigen subsequent to transfection of antigen-presenting cells may explain the lack of inhibition by maternal antibodies of cellular responses. Together, these features make the plasmid vaccines an appealing strategy to prime immune responses against foreign pathogens, during early life. In combination with subsequent boosting using conventional vaccines, DNA vaccine-based regimens may provide a qualitatively superior immunity against microbes. Thorough understanding of immunomodulatory properties of plasmid-vectors may extend their use for early prophylaxis of inflammatory disorders.

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Citations

Apr 6, 2004·Vaccine·Søren KamstrupAnette Bøtner
Jul 8, 2011·Science Translational Medicine·Guzman Sanchez-Schmitz, Ofer Levy
Jun 24, 2003·Infection and Immunity·Alejandra V E CapozzoMarina S Palermo
Dec 1, 2007·Genetic Vaccines and Therapy·Ana Cláudia PelizonAlexandrina Sartori
Dec 5, 2002·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Alexander DalpkeKlaus Heeg
May 16, 2009·Developmental and Comparative Immunology·Rebecca L TallmadgeM Julia B F Flaminio
Dec 2, 2008·Veterinary Immunology and Immunopathology·Srinivas GarlapatiVolker Gerdts
Sep 28, 2006·Reviews in Medical Virology·S van Drunen Littel-van den HurkJ Kovacs-Nolan
Mar 9, 2012·Expert Review of Anti-infective Therapy·Eliana Akemi FutataMaria Notomi Sato

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