Genetic improvement of hip-extended scores in 3 breeds of guide dogs using estimated breeding values: Notable progress but more improvement is needed

PloS One
Eldin A LeightonGail K Smith

Abstract

Two hip quality phenotypes-a hip-extended score assigned by a board certified radiologist and the PennHIP distraction index-were analyzed to estimate genetic parameters and to calculate estimated breeding values used for selecting replacement breeders. Radiographs obtained at 12-18 months of age were available on 5,201 German Shepherd Dogs, 4,987 Labrador Retrievers and 2,308 Golden Retrievers. Obtained by fitting a two-trait model using Bayesian techniques, estimates of heritability for the hip-extended score were 0.76, 0.72, and 0.41 in German Shepherd Dogs, Labrador Retrievers, and Golden Retrievers, respectively, while estimated heritabilities for distraction index were 0.60, 0.66 and 0.59, respectively. Genetic correlations between the two hip quality measures were -0.28 in German Shepherd Dogs, -0.21 in Labrador Retrievers, and -0.29 in Golden Retrievers. Genetic selection for improved hip quality based upon the hip extended score phenotype began in 1980. Among first generation puppies, 34% of 273 German Shepherd Dogs, 55% of 323 Labrador Retrievers, and 43% of 51 Golden Retrievers had an Excellent hip extended score. After 8 generations of selection, mostly based on estimated breeding values derived from the hip extended...Continue Reading

References

Nov 1, 1966·The Journal of Small Animal Practice·B HenricsonS E Olsson
Jun 1, 1997·Pediatric Clinics of North America·J S Donaldson, K A Feinstein
Jul 10, 1998·Journal of the American Animal Hospital Association·W M AdamsE V Nordheim
Feb 7, 2001·The Journal of Bone and Joint Surgery. British Volume·S F JourneauxW J Donnelly
Feb 7, 2001·The Journal of Bone and Joint Surgery. British Volume·S F JourneauxW J Donnelly
Sep 8, 2000·Journal of the American Veterinary Medical Association·A L ReedE A Corley
Dec 8, 2000·Journal of the American Veterinary Medical Association·R D KealyS L Mantz
Dec 29, 2000·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·W M AdamsE V Nordheim
May 7, 2002·Journal of the American Veterinary Medical Association·Richard D KealyHoward D Stowe
Mar 1, 1964·Southern Medical Journal·D R BOELKE, A R CRAIN
Aug 25, 2004·Journal of the American Veterinary Medical Association·Michelle Y PowersGail K Smith
Oct 16, 2004·Journal of Animal Science·J B ColeE A Leighton
Feb 11, 2005·Journal of the American Veterinary Medical Association·Erin R PasterGail K Smith
Sep 5, 2006·Journal of the American Veterinary Medical Association·Gail K SmithRichard D Kealy
Sep 18, 2007·Journal of the American Veterinary Medical Association·Stephanie D SzaboGail K Smith
Oct 3, 2008·American Journal of Veterinary Research·Raluca G MateescuRory J Todhunter
Sep 3, 2010·Journal of the American Veterinary Medical Association·Michelle Y PowersGail K Smith
Oct 16, 2010·PloS One·Zhengkui ZhouRory J Todhunter
Nov 3, 2010·PloS One·Thomas W LewisJohn A Woolliams
Sep 6, 2011·The Veterinary Clinics of North America. Small Animal Practice·Laura L Nelson
Dec 21, 2012·Veterinary Surgery : VS·Gail K SmithRichard D Kealy
Jul 30, 2014·New Zealand Veterinary Journal·M Soo, Aj Worth
May 1, 2015·Applied Psychological Measurement·Seung W Choi, David R King
Oct 3, 2018·Journal of the American Veterinary Medical Association·Lindsey M FejfarMegan K Mueller

❮ Previous
Next ❯

Citations

Nov 12, 2019·Frontiers in Veterinary Science·Stefanie OhlerthUrs Geissbühler
Feb 1, 2020·Theriogenology·Bart J G Broeckx
Jun 2, 2021·The Veterinary Clinics of North America. Small Animal Practice·Pamela S Haney, Robyn R Wilborn
Jun 1, 2021·Frontiers in Veterinary Science·Emily E BrayEvan L MacLean
Sep 24, 2021·Frontiers in Veterinary Science·Frances L ChenElinor K Karlsson

❮ Previous
Next ❯

Software Mentioned

epiR
bayz
HMisc
PennHIP
epibasix
MTDFREML
ggplot2
R
clinfun
RMySQL

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.