Genetic inactivation of D-amino acid oxidase enhances extinction and reversal learning in mice.

Learning & Memory
Viviane LabrieJohn C Roder

Abstract

Activation of the N-methyl-D-aspartate receptor (NMDAR) glycine site has been shown to accelerate adaptive forms of learning that may benefit psychopathologies involving cognitive and perseverative disturbances. In this study, the effects of increasing the brain levels of the endogenous NMDAR glycine site agonist D-serine, through the genetic inactivation of its catabolic enzyme D-amino acid oxidase (DAO), were examined in behavioral tests of learning and memory. In the Morris water maze task (MWM), mice carrying the hypofunctional Dao1(G181R) mutation demonstrated normal acquisition of a single platform location but had substantially improved memory for a new target location in the subsequent reversal phase. Furthermore, Dao1(G181R) mutant animals exhibited an increased rate of extinction in the MWM that was similarly observed following pharmacological administration of D-serine (600 mg/kg) in wild-type C57BL/6J mice. In contextual and cued fear conditioning, no alterations were found in initial associative memory recall; however, extinction of the contextual fear memory was facilitated in mutant animals. Thus, an augmented level of D-serine resulting from reduced DAO activity promotes adaptive learning in response to changing...Continue Reading

References

Aug 25, 1992·Biochimica Et Biophysica Acta·M SasakiJ Enami
Oct 1, 1991·The American Journal of Psychiatry·D C Javitt, S R Zukin
Feb 1, 1983·Genetics·R Konno, Y Yasumura
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·M J SchellS H Snyder
Jan 1, 1995·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·M PitkänenP Riekkinen
Dec 4, 1998·Biological Psychiatry·G TsaiJ T Coyle
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·H WoloskerS H Snyder
May 14, 1999·Current Opinion in Neurobiology·P C Holland, M E Bouton
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·D Manahan-Vaughan, K H Braunewell
Sep 15, 1999·Nature·Y P TangJ Z Tsien
Jan 5, 2000·Journal of Neurocytology·S MorenoM P Cerù
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·J P MothetS H Snyder
Oct 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ilya ChumakovJohn Realson
May 13, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Roger A Nicoll
Nov 20, 2003·Neuroreport·Jamilja A J van der MeulenMatthijs G P Feenstra
Nov 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yunlei YangShumin Duan
Feb 19, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Janne Damm Andersen, Bruno Pouzet
May 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Anne Kemp, Denise Manahan-Vaughan
Aug 3, 2004·Journal of Neuroinflammation·Sheng-Zhou WuSteven W Barger
Nov 13, 2004·The Journal of Biological Chemistry·Veronika N FoltynHerman Wolosker
Jun 9, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kenji HashimotoMasaomi Iyo
Jun 28, 2005·Molecular Genetics and Metabolism·Sabine A FuchsTom J de Koning
Jul 6, 2005·Neuroscience Research·Masao MaekawaYuuichi Hori
Sep 27, 2005·Behavior Genetics·Steven J ClapcoteJohn C Roder
Oct 29, 2005·Nuclear Medicine and Biology·Dagmar BauerKarl-Josef Langen
Nov 22, 2005·Neuroscience Letters·Kazuo ShojiHisanori Suzuki
Nov 23, 2005·Chemical Research in Toxicology·Masao MaekawaRyuichi Konno

❮ Previous
Next ❯

Citations

Sep 24, 2013·Neurobiology of Learning and Memory·Katherine LeaderbrandJelena Radulovic
Sep 30, 2009·Molecular Psychiatry·L VerrallP J Harrison
Jul 16, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karyn M MyersMichael Davis
Jun 2, 2009·Human Molecular Genetics·Viviane LabrieJohn C Roder
Jul 28, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Rana RaisTakashi Tsukamoto
Mar 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jian XuStephen F Heinemann
Aug 22, 2009·Neuroscience and Biobehavioral Reviews·Viviane Labrie, John C Roder
Mar 18, 2010·The Journal of Comparative Neurology·Verona Villar-CerviñoRamón Anadón
Sep 11, 2010·Molecular and Cellular Neurosciences·Philip W J BurnetMatthew J A Wood
Jun 10, 2014·Frontiers in Synaptic Neuroscience·Magalie MartineauJean-Pierre Mothet
Oct 27, 2012·Journal of Pharmacological Sciences·Taku NagaiKiyofumi Yamada
Oct 12, 2010·Behavioural Brain Research·Min ZhangLynne E Rueter
Sep 17, 2016·Neurobiology of Learning and Memory·Alo C BasuJoseph T Coyle
May 27, 2017·Journal of the American Chemical Society·Yonghui WangWei Liu
Jul 22, 2014·The European Journal of Neuroscience·Judith V SchweimerTrevor Sharp
Feb 21, 2018·Frontiers in Psychiatry·Gerson D Guercio, Rogerio Panizzutti
Dec 20, 2017·Frontiers in Molecular Biosciences·Reiko KogaRyuichi Konno
Jan 23, 2019·Psychiatry and Clinical Neurosciences·Yota Uno, Joseph T Coyle
Aug 16, 2012·Amino Acids·Masahiro YamanakaRyuichi Konno
Jan 11, 2020·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Robert A McCutcheonOliver D Howes
Aug 2, 2012·The International Journal of Neuropsychopharmacology·Marco BortolatoJean C Shih
Aug 3, 2012·Expert Review of Neurotherapeutics·Andra MihaliInna Gaisler-Salomon
May 11, 2018·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Ian R WinshipJohn G Howland
May 8, 2019·Biological Chemistry·Ulrika WilhelmssonMilos Pekny
Dec 12, 2020·The International Journal of Neuropsychopharmacology·Lili Veronika NagyIstván Hernádi
May 2, 2013·Journal of Medicinal Chemistry·Seth C HopkinsThomas H Large
Feb 8, 2011·Neuropharmacology·Viviane LabrieJohn C Roder

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.