Genetic influence on the association between bone mineral density and testosterone in Korean men

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
J ShinY-M Song

Abstract

Low bone mineral density (BMD) leads to an increased risk of osteoporotic fracture. Total testosterone and free testosterone were positively associated with BMD, which was significantly influenced by the additive genetic effects. This cross-sectional study aimed to evaluate an association between testosterone and BMD and the influence of genetic factors on the association. Study subjects were 1070 Korean men including 144 pairs of monozygotic twins and their family members. Levels of serum total testosterone and sex hormone binding globulin (SHBG) were measured by chemiluminescence immunoassay. Calculated free testosterone (cFT) was then determined using Vermeulen's method. BMDs of the whole body and specific regions were measured using dual-energy X-ray absorptiometry. Linear mixed regression analyses showed that total testosterone and cFT were positively associated with BMD at most regions, after considering intra-familial relationship and covariates including fat mass, lean mass, and SHBG. SHBG had an inverse association with BMD at the pelvis but not with the BMD at other regions after adjusting for all covariates and cFT. Co-twin control analysis in monozygotic twins found no association between pairwise difference of test...Continue Reading

References

Nov 1, 1991·The Journal of Clinical Endocrinology and Metabolism·A GrayC Longcope
Feb 7, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G A GreendaleE Barrett-Connor
May 23, 1998·American Journal of Human Genetics·L Almasy, J Blangero
Apr 29, 1999·Journal of Endocrinological Investigation·N Fortunati
Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·A VermeulenJ M Kaufman
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·John K AmoryJ Lisa Tenover
Jun 5, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hong-Yo KangKo-En Huang
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·Ville-Valtteri VälimäkiMatti J Välimäki
Feb 8, 2005·Biochemical and Biophysical Research Communications·Wayne BalkanBernard A Roos
Mar 17, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M LeeR M Siervogel
Mar 28, 2008·The Journal of Clinical Endocrinology and Metabolism·Andre B AraujoJohn B McKinlay
Oct 8, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K VenkatM I Khatkhatay
Jun 18, 2010·The Journal of Clinical Endocrinology and Metabolism·Jane A CauleyUNKNOWN Osteoporotic Fractures in Men Study (MrOS) Research Group
Feb 22, 2011·Cell·Franck OuryGerard Karsenty
May 11, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yoshihiro YoshikawaStavroula Kousteni
Jun 10, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J-H ParkY S Park
Oct 15, 2011·PLoS Genetics·Claes OhlssonRobin Haring
Mar 13, 2012·The Journal of Endocrinology·Gerard Karsenty
Dec 12, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Bayasgalan GombojavJoohon Sung
Apr 30, 2013·The Journal of Clinical Endocrinology and Metabolism·Margaret A GatesAndre B Araujo
Sep 4, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F CosmanR Lindsay

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Citations

Sep 21, 2016·American Journal of Men's Health·Sergio Varela KellesarianGeorgios E Romanos
Feb 11, 2019·Oral Diseases·João Daniel Paganella ChavesJoão Paulo Steffens
May 22, 2020·Bone & Joint Research·Alissa GuebeliSabine Rohrmann

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