Genetic influences on cardiovascular responses to an acoustic startle stimulus in rats

Clinical and Experimental Pharmacology & Physiology
V BaudrieJ L Elghozi

Abstract

1. The aim of the present study was to assess the cardiovascular differences among five inbred rat strains (n=16 per strain), including spontaneously hypertensive rats (SHR), Wistar Kyoto (WKY) rats, Wistar Furth (WF) rats, Fischer (F344) rats and Lewis (Lew) rats and the usual outbred Wistar (W) rat strain (n=25). 2. These strains were compared under resting conditions for blood pressure (BP) and heart rate (HR) levels and for their baroreceptor-HR reflex sensitivity. In addition, their responses to an acoustic startle stimulus were measured. 3. A consistent rise in BP was observed among the groups as a result of the noise stimulus. This rise in systolic BP (SBP) averaged (+/-SEM) 37 +/- 2 mmHg in the SHR and 34 +/- 4 mmHg in F344 rats, while the response was only 23 +/- 3 mmHg in WKY rats. Pulse pressure (PP) was increased following noise in all groups. The delay for the BP response for all groups combined was 1.6 +/- 0.1 s. 4. Most animals had minimal HR variations, except F344 rats, responding with a 42 +/- 13 b.p.m. decrease 3.0 s after the stimulus (i.e. 1.3 s after the maximal 34 +/- 4 mmHg SBP rise). 5. The highest SBP (160 +/- 3 mmHg) and diastolic BP (104 +/- 3 mmHg) were observed in inbred SHR. Other groups were norm...Continue Reading

References

Aug 1, 1992·Clinical and Experimental Pharmacology & Physiology·G A Head, M A Adams
Jul 1, 1991·American Journal of Hypertension·A Benetos, M E Safar
Oct 1, 1990·Behavioral Neuroscience·K S Quigley, G G Berntson
Dec 1, 1988·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·R Casto, M P Printz
Jan 1, 1997·Clinical and Experimental Pharmacology & Physiology·J BlancJ L Elghozi
Apr 1, 1997·Behavioural Brain Research·A RamosF Chaouloff
Jan 14, 1998·Journal of Autonomic Pharmacology·V BaudrieJ L Elghozi
Apr 25, 2000·Clinical and Experimental Pharmacology & Physiology·T NabikaY Yamori

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Citations

Jul 9, 2004·Clinical and Experimental Pharmacology & Physiology·Jocelyne BlancJean-Luc Elghozi
Oct 31, 2006·Physiology & Behavior·D ValanceC Leterrier
Jun 14, 2003·Fundamental & Clinical Pharmacology·Laetitia HerinJean-Luc Elghozi
Nov 30, 2018·Frontiers in Behavioral Neuroscience·Adam P SwierczPaul J Marvar

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