Genetic influences on fibrinogen, tissue plasminogen activator-antigen and von Willebrand factor in males and females

Thrombosis and Haemostasis
Marlies de LangeHarold Snieder

Abstract

Differences in genetic influence on death from CHD between males and females have been reported. Haemostatic factors have consistently been associated with risk for coronary heart disease (CHD), but sex differences in genetic architecture have not been studied. This study in middle-aged twins investigates whether there are sex differences in means and in genetic and/or environmental variance components of haemostatic risk factors for CHD. A total of 93 monozygotic twin pairs (44 male and 49 female) and 116 dizygotic twin pairs (36 male, 40 female and 40 opposite sex) were available for this study. Structural equation modelling was used to estimate the relative influence of genetic and environmental factors on variation in levels of fibrinogen, tissue plasminogen activator (tPA) antigen and von Willebrand factor (vWF). Mean levels of tPA and vWF increased with age. Oral contraceptive pill (OCP) and menopause had significant influences on levels of fibrinogen and tPA. Genetic influences explained 39, 66 and 72% of the variation in levels of fibrinogen, tPA and vWF, respectively. No quantitative or qualitative differences of genetic influences on haemostatic levels were seen between males and females. Haemostatic factors may accou...Continue Reading

Citations

Mar 15, 2014·Biochemia Medica·Meltem KilercikIbrahim Unsal
May 30, 2008·American Journal of Hematology·Jochen D Muehlschlegel, Simon C Body
Mar 1, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Jie HuangUNKNOWN CHARGE Consortium Hemostatic Factor Working Group
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Jul 8, 2018·Blood Advances·Ahmad H MuftiUNKNOWN European Group on von Willebrand disease (EU-VWD) and Zimmerman Program for the Molecular and Clinical Biology of von Willeb
Aug 21, 2013·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Melanie NeijtsEco J C de Geus

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