Genetic influences on maternal care

The American Naturalist
Andréa C Peripato, James M Cheverud

Abstract

The basis of social evolution in mammals is the mother-offspring relationship. It is also the primary and most important instance of indirect genetic effects, where genetic variation in one individual affects phenotypic variation among others. This relationship is so important in mammals that often the major factor determining the life or death of newborns is the environment provided by their mother. Variations in these environments can be due to variations in maternal genotypes. In our work with the intercross of two mouse inbred strains, LG/J and SM/J, we uncovered a very severe variation in maternal performance. These females failed to nurture their offspring and showed abnormal maternal behaviors leading to loss of their litter. Rather than this being due to a single gene variant as in knockout mice, we uncovered a complex genetic basis for this trait. The effects of genes on maternal performance are entirely context dependent in our cross. They depend on the alleles present at the same or other epistatically interacting loci. Genomic locations identified in this study include locations of candidate genes whose knockouts displayed similar aberrant maternal behavior. Behaviors significantly associated with maternal performan...Continue Reading

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Citations

Oct 12, 2012·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Carolina P GóesAndrea C Peripato
Jan 28, 2005·Behavior Genetics·Mathias Kölliker
Jun 4, 2004·Nature·Allen J Moore
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·James M Cheverud
Apr 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Donna PetfieldMark W Blows
May 12, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Tomas HrbekJames M Cheverud
May 20, 2004·Journal of Evolutionary Biology·A C PeripatoJ M Cheverud
Dec 2, 2008·Developmental Psychobiology·Alejandro MoyahoJosé R Eguibar
Feb 18, 2011·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Thomas J SangerJames M Cheverud
Aug 9, 2006·Medical Hypotheses·Péter Apari, Lajos Rózsa
Jun 9, 2016·Journal of Neurogenetics·Greer S KirshenbaumSteven J Clapcote
Jul 14, 2005·Proceedings. Biological Sciences·Anne Charmantier, Dany Garant
Oct 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mark R EthertonThomas C Südhof

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